Effect of Raspberry Ketone on Lipid Metabolism and Inflammatory Factors in Hyperlipidemic Rats

Abstract

Abstract: Objective: To explore the effect of raspberry ketone (RK) on lipid metabolism and inflammatory factors in hyperlipidemic rats. Methods: Forty SD rats (half male and half female) were randomly divided into 5 groups. The rats fed normal food were served as normal control group; the rats fed high-fat diets for 4 weeks were administered with RK at the doses of 20, 10 g/L and 5 g/L to create high, middle and low dose groups. The rats in each group were killed after the administration of RK for 8 week. The body weight, visceral index, and serum lipid parameters such as TC, TG, HDL-C and LDL-C, apolipoprotein including apoA-I and apoB, C-reactive protein (hs-CRP), TNF-α and IL-6 were determined. Results: RK could significantly reduce TC, TG and LDL-C levels in hyperlipidemic rats and increase HDL-C content. Meanwhile, serum apoA-I level revealed a significant elevation while apoB revealed an obvious reduction. Moreover, RK could reduce the ratio between liver and body weight, and significantly reduce serum hs-CRP, TNF-α and IL-6 contents. Conclusion: RK not only has a role in regulating blood lipids but also can modulate low inflammation state in hyperlipidemic rats.

Key words: raspberry ketone, hyperlipidemia, lipids, inflammation, rat

CLC Number:

TS255.1

References

[1] Jeppen J, Hein Ho. Suadicani P, et al. Triglyceride concent-ration and ischemic heart disease. An-eighty year follow-up in the Copenhagen male study[J]. Circulation,1998,97:1029-1036
[2] Maseri A. Inflammation,atheroselerosis,and ischemic events: exploring the hidden side of the moon.N.Engl [J]. Med.1997,336:1014.
[3] 赵新军, 张敏州. 通冠胶囊对高血脂大鼠血脂水平和血浆炎症因子的影响[J]. 中西医结合心脑血管病杂志,2007,5（10）:951-952.
[4] Pabst A, Barron D.et al. Studies on the Enzymatic Hydrolysis of Bound Aroma Constituents from Raspber[J]. Agric.Food Chem,1991,39,173-175
[5] Morimoto C; Satoh Y,Hara M.et al. Anti-obese action of raspberry ketone[J] . Life Sciences,2005,77(2):194-204
[6] 孟宪军, 周艳, 刘学．树莓酮对单纯性肥胖大鼠的减肥作用的试验研究[J]. 食品工业,2008，1：1-3
[7] 李长久, 马挺军, 刘诚.复方山楂黄酮的提取及其调脂研究[J]. 食品科学.2006,27(3):216-218
[8] Stienstra R, Duval C, Muller M. Kersten S. PPARs, obesity, and inflammation[J]. PPAR Res, 2007, 11:1-10.
[9] Cosentino F, Assenza GE. Diabetes and inflammation[J]. Herz, 2004, 29(8):749－759.
[10] Schieffer B, Schieffer E, Hilfiker-kleiner D, et al. Expression of angiotensin II and interleukin-6 in human coronary atheroscleroticplaques potential implications for inflammation and plaque instability[J]. Circulation, 2000, 101(12):1372-1378.
[11] Libby P, Ridker PM. Novel inflammatory markers of Coronary risk: theory versur practice [J]. Circulation,1999,100(8):1148-1150
[12] Cawthorn WP,Sethi JK .TNF-alpha and adipocyte biology.FEBS Lett,2008,582(1):117-131
[13] Van Gaal LF,, Mertens IL, De Block CE.Mechanisms linking obesity with cardiovascular disease[J]. Nature, 2006,444:875-880.
[14]Guven A,Cetinkaya A,Aral M,et a1.High-sensitivity C-reactive protein in patients with metabolic syndrome[J].Angi- ology,2006,57(3):295-302
[15] Frohlich M, Imhof A,Berg G. et al. Association between C-reactive protein and features of themetabolic syndrome：a population-based study [J]. Diabetes Care, 2000, 23(12)：1835-1839.