Photosensitive Toxic effect and mechanisms of dibutyl phthalate

Abstract

Abstract: Abstract:The potential harm of dibutyl phthalate (DBP) to environment and organism has been paid more and more attention. In this study, the toxic effect of dibutyl phthalate on photosensitive toxicity was studied. The metabolism and distribution of DBP in plasma and liver were detected by HPLC after intragastric administration of DBP in male rats. The contents of reactive oxygen species (ROS), malondialdehyde(MDA), glutathione (GSH) and superoxide dismutase (SOD) in rat liver and kidney were determined, and the pathological sections of liver and kidney were observed. Pharmacokinetics showed that sunlight can promote the transformation of DBP into MBP, and MBP content in liver and kidney was higher than that in other organs. MBP could significantly increase ROS and MDA, in rat liver and kidney. The decrease of GSH and SOD, showed that MBP can induce lipid peroxidation in rat liver and induce early liver injury. Pathological sections showed that light can enhance the damage of MBP to rat liver and kidney cells. Therefore, DBP is a potentially harmful phototoxic substance in male rats.

Key words: dibutyl phthalate(DBP) , photosensitive toxicity, lipid peroxidation injury, liver injury, kidney injury, pathological changes

CLC Number:

R285.5

References

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