Protective Effect of Grape Seed Oligomeric Proanthocyanidins Extract against Cisplatin-Induced Nephrotoxicity in HEK293 Cell and Effect on Anticancer Activity of Cisplatin in Human Lung Cancer Cells

doi:10.7506/spkx1002-6630-201607033

Abstract

Abstract:

Objective: To investigate the protective effect of grape seed oligomeric proanthocyanidins extract (GSOPE) and
catechin (C) against cisplatin (DDP)-induced nephrotoxicity in human embryonic kidney (HEK) 293 cells and its effect on
anticancer activity of DDP in human lung cancer A549 cells. Methods: HEK293 cells and A549 cells were cultured in vitro.
The protective effects of GSOPE and catechin at various concentrations on DDP-induced HEK293 cells and their synergistic
interaction with DDP against A549 cells were evaluated by MTT assay. Results: GSOPE at 16 mg/L could significantly
protect DDP-induced HEK239 cells from death (P < 0.05), and the protective effect was better than that of other groups.
GSOPE at 16 mg/L could also significantly enhance DDP-induced A549 cell death (P < 0.05). On the other hand, catechin
had no influence on DDP-induced HEK293 cell death. Conclusion: In vitro, GSOPE, rather than catechin, can protect
DDP-induced nephrotoxicity and can enhance DDP-induced lung cancer cell death.

Key words: grape seed oligomeric proanthocyanidins extract (GSOPE), catechin, cisplatin, nephrotoxicity

CLC Number:

Q946.8

LIAN Yanna, GAO Liping, GUO Yu, GAO Zhaolan, JIN Yu. Protective Effect of Grape Seed Oligomeric Proanthocyanidins Extract against Cisplatin-Induced Nephrotoxicity in HEK293 Cell and Effect on Anticancer Activity of Cisplatin in Human Lung Cancer Cells[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201607033.

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Protective Effect of Grape Seed Oligomeric Proanthocyanidins Extract against Cisplatin-Induced Nephrotoxicity in HEK293 Cell and Effect on Anticancer Activity of Cisplatin in Human Lung Cancer Cells

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