食品科学 ›› 2009, Vol. 30 ›› Issue (3): 21-24.doi: 10.7506/spkx1002-6630-200903002

• 基础研究 • 上一篇    下一篇

乙醇提取樟芝菌粉三萜类化合物的动力学研究

陆震鸣1,陶文沂1,许泓瑜1,敖宗华1,张晓梅2,许正宏1.2   

  1. 1.江南大学 工业生物技术教育部重点实验室 2.江南大学医药学院制药工程研究室
  • 收稿日期:2008-03-06 修回日期:2008-08-04 出版日期:2009-02-01 发布日期:2010-12-29
  • 通讯作者: 陆震鸣 E-mail:zhenming_lu@yahoo.com.cn
  • 基金资助:

    教育部新世纪人材支持计划项目(NCET-07-0380);国家“863”重点项目(2007AA021506);
    国家“973”项目(2007CB707804)

Kinetics on Extraction of Triterpenoids from Antrodia camphorata

LU Zhen-ming1, TAO Wen-yi1,*,XU Hong-yu2,AO Zong-hua1,ZHANG Xihao-mei2,XU Zheng-hong1,2   

  1. (1.Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China ;
    2. Laboratory of Pharmaceutical Engineering, School of Medicine and Pharmaceutics, Jiangnan University, Wuxi 214122, China)
  • Received:2008-03-06 Revised:2008-08-04 Online:2009-02-01 Published:2010-12-29
  • Contact: LU Zhen-ming1 E-mail:zhenming_lu@yahoo.com.cn

摘要:

以Fick 扩散第二定律为基础,建立樟芝菌粉三萜提取过程的动力学方程,并由此推算出提取的速率常数、活化能、相对萃余率、半衰期,以及内扩散系数等动力学函数值。结果表明:所得提取模型能较好地描述樟芝菌粉三萜类化合物提取的动态过程。樟芝菌粉三萜类化合物提取过程的动力学符合一级动力学方程,为内扩散控制动力学。本研究可为樟芝三萜类化合物提取的工艺设计及操作条件的选择提供有价值的理论依据。

关键词: 樟芝, 液体发酵, 三萜, 提取, 动力学

Abstract:

The Fick's second law of diffusion was used to establish the kinetics equation of extracting triterpenoid parameters from Antrodia camphorata in submerged fermentation. The extraction process was analyzed to obtain kinetics parameters, such as K (rate constant), Ea (activation energy), y (yield), t1/2 (half life)and Ds (internal diffusion coefficient). The results showed that the kinetics on the extraction of triterpenoids match the first-order rate equation, and the rate-determining step for extraction is the diffusion of triterpenoids through particles. The method would be useful for the process design and the choice of operation condition to extract triterpenoids from Antrodia camphorata in subm erged fermentation.

Key words: Antrodia camphorata, submerged culture, triterpenoid, extraction, kinetics

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