食品科学 ›› 2009, Vol. 30 ›› Issue (3): 267-269.doi: 10.7506/spkx1002-6630-200903060

• 营养卫生 • 上一篇    下一篇

裙带菜膳食纤维降血压及机制研究

肖红波1,卢向阳2,孙志良1,罗志峰3,易金娥1   

  1. 1.湖南农业大学动物医学院 2.湖南农业大学生化与发酵工程实验室 3.湘南学院基础医学系
  • 收稿日期:2008-02-14 修回日期:2008-09-01 出版日期:2009-02-01 发布日期:2010-12-29
  • 通讯作者: 肖红波 E-mail:x2hb@yahoo.com.cn
  • 基金资助:

    湖南农业大学动物医学院基金项目(BK0717);湖南农业大学青年基金项目(04QN03)

Study on Blood Pressure-lowering Effect of Undaria pinnatifida Dietary Fiber and Its Mechanism

XIAO Hong-bo1,LU Xiang-yang2,SUN Zhi-liang1,LUO Zhi-feng3,YI Jin-e1   

  1. (1.College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China;2. Laboratory of Biochemistry and
    Fermentation Engineering, Hunan Agricultural University, Changsha 410128, China;3. Department of Basic Medicine, Xiangnan
    University, Chenzhou 423000, China)
  • Received:2008-02-14 Revised:2008-09-01 Online:2009-02-01 Published:2010-12-29
  • Contact: XIAO Hong-bo1 E-mail:x2hb@yahoo.com.cn

摘要:

40 只大鼠分为4 组(n=10):正常对照组、自发性高血压大鼠组、膳食纤维低剂量组(5%)、膳食纤维高剂量组(10%) 。经裙带菜膳食纤维处理8w 后,检测离体血管的内皮依赖性舒张效应、尾动脉收缩压、血浆一氧化氮(NO)水平,并用Western 印迹检测内皮型一氧化氮合酶(eNOS)蛋白表达水平,发现裙带菜可溶性膳食纤维显著降低尾动脉收缩压,显著改善内皮功能及血浆NO 的水平并伴随着eNOS 蛋白表达水平的上调。这些结果表明,裙带菜膳食纤维能降低自发性高血压大鼠的尾动脉收缩压,这可能与增加NO 的产生来改善其内皮功能有关。

关键词: 裙带菜, 膳食纤维, 一氧化氮, 内皮型一氧化氮合酶, 大鼠

Abstract:

40 rats were divided into 4 groups (n=10) as control group, spontaneous hypertension rat (SHR) group, low dose dietary fiber-treated group (5%), and high dose dietary fiber-treated group (10%). After 8 weeks of treatment, the endotheliumdependent vasorelaxation in isolated aortic rings, systolic pressure of tail artery and content of plasma nitric oxide (NO) were determined. The protein expression of endothelial NO synthase (eNOS) was measured by using Western blot. It was found that Undaria pinnatifida dietary fiber treatment can significantly decrease systolic pressure of tail artery, and improve endothelial function accompanied with plasma NO level increasing via the unregulation of expression of eNOS protein. All theses indicates that Undaria pinnatifida soluble dietary fiber in SHR rats could decrease blood pressure. The improvement of endothelial function by increasing NO production may cause this result.

Key words: Undaria pinnatifida, dietary fiber, nitric oxide, endothelial nitric oxide synthase, rat

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