食品科学 ›› 2011, Vol. 32 ›› Issue (15): 251-254.doi: 10.7506/spkx1002-6630-201115055

• 营养卫生 • 上一篇    下一篇

小米酸不溶性蛋白抗四氯化碳肝损伤的研究

许 洁,王常青*,赵陈勇,樊 迎,王 菲   

  1. 山西大学 生命科学学院
  • 收稿日期:2018-04-20 修回日期:2018-04-20 出版日期:2011-08-15 发布日期:2011-07-26

Protective Effect of Acid-insoluble Protein from Millet against CCl4-induced Liver Injury in Mice

XU Jie,WANG Chang-qing*,ZHAO Chen-yong,FAN Ying,WANG Fei   

  1. (College of Life Science, Shanxi University, Taiyuan 030006, China)
  • Received:2018-04-20 Revised:2018-04-20 Online:2011-08-15 Published:2011-07-26

摘要: 研究小米酸不溶性蛋白对CCl4所致小鼠肝损伤动物模型的保肝作用。结果显示:小米酸不溶性蛋白处理组与肝损伤对照组相比,小米酸不溶性蛋白处理组的动物血清中谷丙转氨酶(ALT)、谷草转氨酶(AST)水平及肝组织中丙二醛(MDA)含量显著降低(P<0.05),并且,小鼠肝脏表面形态异常症状减轻,小米酸不溶性蛋白处理组的肝细胞坏死、脂肪变性和炎性细胞浸润等病变较少,其中小米酸不溶性蛋白高剂量组的效果最佳。结果表明,小米酸不溶性蛋白对CCl4所致动物急性肝损伤具有保护作用。

关键词: 小米, CCl4肝损伤, 酸不溶性蛋白质

Abstract: In this paper, the protective effect of acid-insoluble protein from millet against CCl4-induced liver injury in mice was explored. The results indicated that serum ALT and AST levels and hepatic MDA content in mice treated with acid-insoluble protein from millet were significantly lower than those in mice from the liver damage model group (P <0.05). Meanwhile, abnormal morphology of mouse liver surface, necrosis of liver cells, steatosis and inflammatory cells infiltration were reduced by dietary administration with acid-insoluble protein from millet in a dose-dependent manner. Therefore, millet acid insoluble protein can protect mice from acute liver injury induced by CCl4.

Key words: millet, acid-insoluble protein, CCl4-induced liver injury, protective capability

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