食品科学
• 专题论述 • 上一篇
卢永忠,康道乐
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LU Yongzhong, KANG Daole
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摘要:
抗菌肽在医药、食品、农业及水产等领域具有潜在的应用价值,定量构效关系(quantitative structureactivityrelationships,QSAR)研究对于指导抗菌肽的优化设计具有重要意义。本文介绍抗菌肽在分子表征及建模等方面取得的研究进展,比较抗菌肽与其他小肽在QSAR研究中的异同,指出其中存在的问题及今后的研究发展方向。
关键词: 抗菌肽, 定量构效关系, 描述符, 氨基酸, 数学模型
Abstract:
Antimicrobial peptides have potential applications in many fields, such as medicine, food, agriculture, and aquiculture. Quantitative structure-activity relationships (QSAR) research will be helpful for the optimization of antimicrobial peptides. Herein, the recent progress in molecular description and modeling of antimicrobial peptides in comparison to oligo peptides is reviewed. Meanwhile, the existing problems and the future trends are also discussed.
Key words: antimicrobial peptide, quantitative structure-activity relationship, descriptor, amino acid, mathematical model
中图分类号:
Q74
卢永忠,康道乐. 抗菌肽的定量构效关系研究进展[J]. 食品科学, doi: 10.7506/spkx1002-6630-201515055.
LU Yongzhong, KANG Daole. Progress in Quantitative Structure-Activity Relationships Research of Antimicrobial Peptides[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201515055.
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链接本文: https://www.spkx.net.cn/CN/10.7506/spkx1002-6630-201515055
https://www.spkx.net.cn/CN/Y2015/V36/I15/299