库拉索芦荟对黄曲霉毒素B1致大鼠急性肝损伤的保护作用

doi:10.7506/spkx1002-6630-201607032

食品科学

库拉索芦荟对黄曲霉毒素B1致大鼠急性肝损伤的保护作用

崔燕1,2，凌建刚1，姚卫蓉2，康孟利1，俞静芬1，林旭东1，尚海涛1，朱麟1，钱和2,*

1.宁波市农业科学研究院农产品加工研究所，浙江宁波 315040；2.江南大学食品学院，江苏无锡 214122

出版日期:2016-04-15 发布日期:2016-04-13

Protective Effect of Aloe vera against Aflatoxin B1-Induced Acute Hepatotoxicity in Rats

CUI Yan1,2, LING Jiangang1, YAO Weirong2, KANG Mengli1, YU Jingfen1, LIN Xudong1, SHANG Haitao1, ZHU Lin1, QIAN He2,*

1. Institute of Agricultural Products Processing, Ningbo Institute of Agricultural Sciences, Ningbo 315040, China;
2. School of Food Science and Technology, Jiangnan University, Wuxi 214122, China

Online:2016-04-15 Published:2016-04-13

摘要/Abstract

摘要：

目的：研究库拉索芦荟在黄曲霉毒素B1（aflatoxin B1，AFB1）致大鼠急性肝损伤中的干预作用及机理。方法：采用单次灌胃2.0 mg/kg（以体质量计）AFB1建立大鼠急性AFB1肝损伤模型，通过体质量、肝功能指标、肝组织病理学变化评价库拉索芦荟的干预效果，并通过测定肝组织脂质过氧化产物、各抗氧化物水平，探讨库拉索芦荟拮抗急性AFB1肝毒性的作用机理。结果：库拉索芦荟具有显著降低急性AFB1肝毒性的功效，能有效抑制急性AFB1中毒大鼠体质量下降，降低血清谷丙转氨酶（glutamate pyruvate transaminase，GPT）、谷草转氨酶（glutamicoxalacetic transaminase，GOT）和碱性磷酸酶（alkaline phosphatase，ALP）活性以及总胆红素（total bilirubin，TBIL）含量；同时能显著改善肝脏组织病变情况，降低丙二醛（malondialdehyde，MDA）生成量，提高还原型谷胱甘肽（reduced glutathione，GSH）含量以及谷胱甘肽过氧化物酶（glutathione peroxidase，GSH-Px）、超氧化物歧化酶（superoxide dismutase，SOD）、谷胱甘肽-S-转移酶（glutathione-S-transferases，GST）活力，增强机体抗氧化及解毒能力。

关键词: 库拉索芦荟, 黄曲霉毒素B1致肝损伤, 护肝, 氧化应激, 解毒

Abstract:

Objective: To investigate the possible hepatoprotective activity of Aloe vera against aflatoxin B1 (AFB1)-induced
liver damage and its underlying mechanisms. Methods: The acute AFB1-intoxicated rat model was established by intragastric
administration of AFB1 at the dose of 2.0 mg/kg. The hepatoprotective effect of Aloe vera on AFB1-intoxicated rats was evaluated
by measuring body weight, serum markers and histopathological examination. And the mechanisms involved were elucidated
by measuring the levels of lipid peroxidation and antioxidants in livers. Results: The treatment of Aloe vera effectively inhibited
the body weight loss in AFB1-intoxicated rats, and significantly reduced serum glutamate pyruvate transaminase (GPT), glutamic
oxalacetic transaminase (GOT), alkaline phosphatase (ALP), and total bilirubin (TBIL) levels. In addition, Aloe vera was shown to
be effective in improving hepatic histopathological changes, lowering malondialdehyde (MDA), and elevating the levels of reduced
glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and glutathione-S-transferase (GST). These
results suggest that Aloe vera can remarkably enhance the antioxidant and detoxifying capacities of AFB1-intoxicated rats, and
possesses a potent protective effect against AFB1-induced hepatotoxicity.

Key words: Aloe vera, aflatoxin B1-induced liver injury, hepatoprotection, oxidative stress, detoxication

中图分类号:

TS201.4

崔燕，凌建刚，姚卫蓉，康孟利，俞静芬，林旭东，尚海涛，朱麟，钱和. 库拉索芦荟对黄曲霉毒素B1致大鼠急性肝损伤的保护作用[J]. 食品科学, doi: 10.7506/spkx1002-6630-201607032.

CUI Yan, LING Jiangang, YAO Weirong, KANG Mengli, YU Jingfen, LIN Xudong, SHANG Haitao, ZHU Lin, QIAN He. Protective Effect of Aloe vera against Aflatoxin B1-Induced Acute Hepatotoxicity in Rats[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201607032.

[1]	祝敏，靳林，赵浩安，王倩，张锦锦，杨二林，曹炜. 紫穗槐蜂蜜对小鼠急性酒精性胃溃疡的预防作用[J]. 食品科学, 2021, 42(9): 77-84.
[2]	杨成林，黄超，刘娟，黄卫梅，袁志航，易金娥，梁曾恩妮，邬静. 桦木酸对T-2毒素诱导小鼠肝损伤的保护作用[J]. 食品科学, 2021, 42(9): 107-114.
[3]	黄琳琳，张一敏，朱立贤，梁荣蓉，罗欣，成海建，毛衍伟. 蛋白质氧化和翻译后修饰对肉品质的影响及机制研究进展[J]. 食品科学, 2021, 42(9): 241-247.
[4]	杨忠敏，沈以红，黄先智，王祖文，丁晓雯. 桑叶生物碱对氧化应激小鼠糖脂代谢异常及肝损伤的改善作用[J]. 食品科学, 2021, 42(7): 156-161.
[5]	黄燕婷，梅丽华，潘海博，覃璐琪，饶川艳，聂梦琳，朱雯君，李全阳. 巴马长寿特征饮食模式对自然衰老小鼠的抗衰老效果[J]. 食品科学, 2021, 42(5): 137-144.
[6]	陈慧, YOSHINORI Katakura, 扈洪波, 尹淑涛, 赵冲. SIRT3多酚激活剂的筛选及其对UVB诱导HaCaT细胞衰老的修复作用[J]. 食品科学, 2021, 42(5): 115-121.
[7]	何萍萍，郑雅君，郑明静，姜泽东，杜希萍，朱艳冰，倪辉，李清彪. 红毛藻多糖对H2O2诱导的Caco-2细胞氧化损伤的保护作用[J]. 食品科学, 2021, 42(17): 113-120.
[8]	周宏炫，黄颖，谭书明，涂永丽，罗继伟. 刺梨多酚对急性酒精中毒大鼠的解酒和护肝作用[J]. 食品科学, 2021, 42(17): 163-169.
[9]	李西栋，孙绍霞，梁亚楠，石塔拉，宓伟. 山楂原花青素和VC联合通过Wnt/β-catenin通路减轻胰岛素抵抗大鼠肝脏氧化应激[J]. 食品科学, 2021, 42(17): 186-192.
[10]	杨诗怡，林巍，杨丽玉，左成，罗勤. CodY在单核细胞增生李斯特菌抗氧化胁迫中的作用[J]. 食品科学, 2021, 42(14): 46-53.
[11]	胡博然，丁建才，曹杨，田颖，国凤华，袁静. (＋)-儿茶素与表没食子儿茶素没食子酸酯对乙醇诱导HepG2细胞脂代谢紊乱及氧化应激的影响[J]. 食品科学, 2021, 42(13): 114-120.
[12]	华梅，樊美玲，李志满，董丽娜，李珊珊，孙印石. 人参水溶性膳食纤维对大鼠糖脂代谢、氧化应激和肠道健康的影响[J]. 食品科学, 2021, 42(13): 127-135.
[13]	牙甫礼，XIN Yu，张春梅，陈彬林，李玮琪，马永洁. 姜黄素对H2O2诱导血小板凋亡的抑制作用及分子机制[J]. 食品科学, 2021, 42(13): 151-157.
[14]	王新怡，张一敏，梁荣蓉，董鹏程，罗欣，毛衍伟. 过氧化物氧化还原酶6调控肉品嫩度的研究进展[J]. 食品科学, 2021, 42(11): 236-243.
[15]	刘子微，朱建津，陈巍文，李浙烽. 阿魏酸类似物对强的松诱导的小鼠氧化应激的影响[J]. 食品科学, 2021, 42(1): 163-171.

库拉索芦荟对黄曲霉毒素B1致大鼠急性肝损伤的保护作用

Protective Effect of Aloe vera against Aflatoxin B1-Induced Acute Hepatotoxicity in Rats

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价