食品科学 ›› 2019, Vol. 40 ›› Issue (20): 54-59.doi: 10.7506/spkx1002-6630-20181022-236

• 食品化学 • 上一篇    下一篇

pH值响应型负载白藜芦醇微胶囊的制备与抗氧化活性分析

邓姣,刘鑫,成文豪,刘田田,周军,李湘洲   

  1. (1.中南林业科技大学材料科学与工程学院,湖南 长沙 410004;2.南方林业生态应用技术国家工程实验室,湖南 长沙 410004)
  • 出版日期:2019-10-25 发布日期:2019-10-25
  • 基金资助:
    “十三五”国家重点研发计划重点专项(2016YDF0600805)

DENG Jiao, LIU Xin, CHENG Wenhao, LIU Tiantian, ZHOU Jun, LI Xiangzhou

DENG Jiao, LIU Xin, CHENG Wenhao, LIU Tiantian, ZHOU Jun, LI Xiangzhou   

  1. (1. School of Material Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China; 2. National Engineering Laboratory for Applied Technology of Forestry & Ecology in South China, Changsha 410004, China)
  • Online:2019-10-25 Published:2019-10-25

摘要: 目的:制备并获得具有pH值响应和抗氧化活性的紫胶树脂铵盐(shellac resin ammonium salt,SRAS)/白藜芦醇(resveratrol,RES)微胶囊,提高RES的生物利用率。方法:SRAS为壁材,利用喷雾干燥技术对RES进行微胶囊化,获得SRAS/RES微胶囊,并利用扫描电镜、傅里叶变换红外光谱、差示扫描量热等技术对其性能进行表征,研究其抗氧化活性以及在不同pH值条件下的释放效果。结果:在配方中SRAS、RES和吐温80的用量分别为2、0.278 g和0.5 g的条件下,制备的SRAS/RES微胶囊中RES的包埋率为82.70%,负载率为8.27%;SRAS/RES微胶囊为表面光滑的球体结构,热力学性质稳定,抗氧化能力高于未包埋前的RES,具有pH值响应性,其在模拟人体胃液环境下保持缓释释放,而在模拟人体肠液中快速释放。结论:天然紫胶树脂经氨水改性得到的SRAS可用于包埋RES,制备的SRAS/RES微胶囊具有促进RES在肠液中的吸收与利用的作用,在功能食品、药品输送体系中具有一定的应用前景。

关键词: 白藜芦醇, 紫胶树脂铵盐, 微胶囊, 抗氧化活性, pH值响应性

Abstract: Objective: Shellac resin ammonium salt (SRAS) was used to prepare the SRAS/resveratrol (RES) microcapsules with pH response and antioxidant activity in order to improve the bioavailability of RES. Methods: SRAS was used as wall material for RES microencapsulation by spraying drying, and the properties of SRAS/RES microcapsules were characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC), and antioxidant activities and release behaviors under different pH conditions were studied as well. Results: The microencapsulation efficiency was 82.70%, and the load rate was 8.27% when 2 g of SRAS, 0.278 g of RES and 0.5 g of Tween 80 were used in the formulation. SRAS/RES microcapsules were microspheres with smooth surfaces, and had good thermodynamic stability. The antioxidant capacity of RES was increased after microencapsulation, and the microcapsules had pH responsiveness and could slowly release RES in simulated human gastric fluid but rapidly in simulated human intestinal fluid. Conclusion: SRAS, modified shellac with ammonia water, can be used for RES microencapsulation. SRAS/RES microcapsules can facilitate the absorption and utilization of RES in the intestinal liquid and show great promise in delivery systems for functional foods and drugs.

Key words: resveratrol, shellac resin ammonium salt, microcapsules, antioxidant activity, pH response

中图分类号: