食品科学 ›› 2021, Vol. 42 ›› Issue (5): 349-359.doi: 10.7506/spkx1002-6630-20200212-118

• 专题论述 • 上一篇    

枸杞多糖的生物活性及作用机制研究进展

谢文,陈华国,赵超,龚小见,周欣   

  1. (贵州师范大学,贵州省山地环境信息系统与生态环境保护重点实验室,贵州省药物质量控制及评价技术工程实验室,天然药物质量控制研究中心,贵州 贵阳 550001)
  • 出版日期:2021-03-15 发布日期:2021-03-29
  • 基金资助:
    贵州省科技计划项目(黔科合支撑[2018]2826);贵州省高层次创新人才培养项目(黔科合人才[2015]4033号); 贵州省优秀青年科技人才项目(黔科合平台人才[2017]5625); 贵州省普通高等学校科技拔尖人才支持计划项目(黔教合KY字[2017]065)

Recent Progress in Understanding the Bioactivity and Mechanism of Action of Lycium barbarum Polysaccharide

XIE Wen, CHEN Huaguo, ZHAO Chao, GONG Xiaojian, ZHOU Xin   

  1. (Guizhou Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Engineering Laboratory for Quality Control and Evaluation Technology of Medicine, Research Center for Quality Control of Natural Medicine, Guizhou Normal University, Guiyang 550001, China)
  • Online:2021-03-15 Published:2021-03-29

摘要: 枸杞子是中国传统的中药材和食品补品,枸杞子中具有多种活性成分,如枸杞多糖、黄酮类化合物、生物碱、枸杞色素、氨基酸类等。大量研究表明,枸杞子中最具有提取利用价值的是枸杞多糖,其具有抗肿瘤、抗氧化、抗衰老、抗炎、降血糖、降血脂、神经保护、生殖保护、保肝、护眼、免疫调节等作用。本文系统总结了近年来关于枸杞多糖生物活性及作用机制的研究,并在此基础上展望枸杞多糖研究方向与应用前景,以期为枸杞多糖相关保健品及辅助治疗药物的开发利用提供参考。

关键词: 枸杞多糖;生物活性;作用机制;抗肿瘤;抗氧化;神经保护作用;药食同源

Abstract: The fruit of Lycium barbarum is both a traditional Chinese medicinal material and dietary supplement, which contains various bioactive components, such as polysaccharides, flavonoids, alkaloids, pigments, and amino acids. A large number of studies showed that polysaccharides are the bioactive component with the highest extraction and utilization value in the fruit of Lycium barbarum due to its multiple biological functions such as anti-tumor, antioxidant, anti-aging, anti-inflammatory, hypoglycemic, hypolipidemic, neuroprotective, reproductive system-protecting, eye-protecting and immune-regulating effects. In this review, recent advances are systematically summarized in understanding the biological activities and mechanism of action of Lycium barbarum polysaccharide (LBP). Furthermore, future research directions and potential applications are presented. We hope that this review will provide useful information for the development of LBP-based nutraceuticals and auxiliary drugs.

Key words: Lycium barbarum polysaccharides; biological activities; mechanism of action; antitumor; antioxidant; neuroprotective effect; medicine and food homology

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