食品科学 ›› 2021, Vol. 42 ›› Issue (19): 291-298.doi: 10.7506/spkx1002-6630-20200520-229

• 专题论述 • 上一篇    

补充益生菌对肥胖机体免疫调节作用的研究进展

蒙双利,孟荟萃   

  1. (1.中山大学公共卫生学院(深圳),广东 深圳 518106;2.广东省营养膳食与健康重点实验室,广东 广州 510080;3.广东省营养转化工程技术研究中心,广东 广州 510080)
  • 发布日期:2021-11-12
  • 基金资助:
    国家自然科学基金青年科学基金项目(81903301)

Progress in the Immunomodulatory Effect of Probiotic Supplementation in Obese Subjects

MENG Shuangli, MENG Huicui   

  1. (1. School of Public Health (Shenzhen), Sun Yat-Sen University, Shenzhen 518106, China; 2. Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou 510080, China; 3. Guangdong Engineering Technology Research Center of Nutrition Translation, Guangzhou 510080, China)
  • Published:2021-11-12

摘要: 肥胖不仅会诱发慢性代谢性疾病,还会导致免疫功能的损伤,降低生活质量。益生菌是对宿主健康起促进作用的活菌,具有免疫调节作用。本文综述了补充益生菌对肥胖机体适应性免疫与固有免疫的作用,讨论了菌株特异性、益生菌补充剂量、补充方式、宿主状态等对免疫调节效果的影响,旨在进一步加深补充益生菌对肥胖机体免疫调节作用的认识,为合理应用益生菌提供参考。

关键词: 益生菌;肥胖;适应性免疫;固有免疫

Abstract: Obesity not only initiates chronic metabolic diseases, but also causes damage to the immune function and a reduction in the quality of life. Probiotics are living bacteria which can promote host health and has immunoregulatory functions. This review summarizes the immunomodulatory effect of supplementary probiotics on the innate immunity and adaptive immunity of obese subjects and discusses the influence of strain specificity, dosage, supplementation regimes and host status on the immunomodulatory effect. This review provides a better understanding of the immunomodulatory effect of probiotic supplementation on obese subjects, which will provide a reference for the rational application of probiotics.

Key words: probiotics; obesity; adaptive immunity; innate immunity

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