食品科学 ›› 2021, Vol. 42 ›› Issue (19): 250-259.doi: 10.7506/spkx1002-6630-20200914-166

• 专题论述 • 上一篇    

益生菌和粪菌移植调节炎症性肠病的研究进展

田亚针,张晨曦,杨涛,代晓斐,刘维鹏,满朝新,张微,姜毓君   

  1. (东北农业大学食品学院,乳品科学教育部重点实验室,黑龙江 哈尔滨 150030)
  • 发布日期:2021-11-12
  • 基金资助:
    国家自然科学基金面上项目(31871828);“十三五”国家重点研发计划重点专项 (2018YFE0120500)

Progress in Understanding the Role of Probiotics and Fecal Microbiota Transplantation in Regulating Inflammatory Bowel Disease

TIAN Yazhen, ZHANG Chenxi, YANG Tao, DAI Xiaofei, LIU Weipeng, MAN Chaoxin, ZHANG Wei, JIANG Yujun   

  1. (Key Laboratory of Dairy Science, Ministry of Education, School of Food Science, Northeast Agricultural University, Harbin 150030, China)
  • Published:2021-11-12

摘要: 炎症性肠病(inflammatory bowel diseases,IBD)是一种易复发的慢性胃肠道炎症性疾病,近年来在世界范围内的发病率逐渐上升。IBD的发病因素复杂,主要是由遗传、环境、免疫等因素相互作用导致的,随着宿主-肠道微生物相互作用的深入研究,人们发现肠道菌群在IBD的进展中发挥着重要作用,因此基于调节肠道微生物群缓解或治疗IBD的新型方法也备受关注。近年来的大量研究都表明益生菌、粪菌移植可以通过调节肠道微生物的组成、增强肠道屏障功能、调节机体免疫反应等达到缓解IBD的目的。因此,本文对IBD的发病因素以及益生菌、粪菌移植调节IBD的研究进展进行综述。

关键词: 炎症性肠病;溃疡性结肠炎;克罗恩病;肠道菌群;肠道屏障;益生菌;粪菌移植

Abstract: Inflammatory bowel disease (IBD) is a chronic and recurrent gastrointestinal?inflammatory disease, whose incidence is increasing worldwide in recent years. Its pathogenesis is complicated, which is mainly caused by the interaction of genetic, environmental and immune factors. Intensive studies of the host-gut microbial interaction have demonstrated that the intestinal microflora plays an important role in the development of IBD. Therefore, there is tremendous interest in developing new methods to relieve and treat IBD by regulating the gut microbiota. In recent years, a large number of studies have proved that probiotics and fecal microbiota transplantation (FMT) may alleviate IBD by regulating the composition of intestinal microflora, enhancing the mucosal barrier function and regulating the immune response. This article reviews the recent progress in the pathogenesis of IBD and the application of probiotics and fecal bacteria transplantation on IBD.

Key words: inflammatory bowel diseases; ulcerative colitis; Crohn’s disease; gut microbiota; intestinal barrier; probiotics; fecal microbiota transplantation

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