食品科学 ›› 2021, Vol. 42 ›› Issue (21): 322-330.doi: 10.7506/spkx1002-6630-20200926-327

• 专题论述 • 上一篇    下一篇

植物源活性成分降血糖作用及其机理研究进展

金斐,朱丽云,,高永生,赵前,徐晓晖,娄成楠   

  1. (1.中国计量大学生命科学学院,浙江 杭州 310018;2.中国计量大学现代科技学院,芳香工程技术研发中心,浙江 杭州 310018;3.安徽汉芳生物科技有限公司,安徽 淮北 235000)
  • 出版日期:2021-11-15 发布日期:2021-11-23
  • 基金资助:
    浙江省自然科学基金项目(LY20C200004);国家市场监督管理总局科技计划项目(S2020MK990); 全国大学生生命科学竞赛项目(202151415)

Progress in Research on the Hypoglycemic Effect and Mechanism of Plant-Derived Active Ingredients

JIN Fei, ZHU Liyun,, GAO Yongsheng, ZHAO Qian, XU Xiaohui, LOU Chengnan   

  1. (1. College of Life Sciences, China Jiliang University, Hangzhou 310018, China; 2. Aromatic Engineering Technology Research and Development Center, College of Modern Science and Technology, China Jiliang University, Hangzhou 310018, China; 3. Anhui Hanfang Biotechnology Co., Ltd., Huaibei 235000, China)
  • Online:2021-11-15 Published:2021-11-23

摘要: 糖尿病是以高血糖为主要特征的一种代谢性疾病,控制并降低血糖是治疗糖尿病的有效途径,研究与开发优于传统药物的天然植物源活性成分,探讨其降血糖作用及机理,对糖尿病的预防与治疗意义重大。本文分析了目前常用降血糖中成药的成分和作用效果,围绕非挥发性和挥发性两类植物源降血糖活性物质,主要从实验模型、降血糖作用与机理3 个方面对多糖、皂苷、多酚、生物碱等非挥发性活性物质和植物精油、部分单体成分等挥发性活性物质进行了阐述,为植物源降血糖活性成分在糖尿病防御方面的进一步研究、开发和应用提供理论依据。

关键词: 植物提取物;非挥发性物质;挥发性物质;降血糖;作用机理

Abstract: Diabetes is a metabolic disease characterized by hyperglycemia. Controlling and lowering blood glucose is an effective way to treat diabetes. Discovering and developing natural plant-derived active ingredients superior to traditional antidiabetic agents and exploring their hypoglycemic effects and mechanisms are of great significance for the prevention and treatment of diabetes. This paper analyzes the ingredients and potency of the traditional Chinese patent medicines commonly used for lowering blood glucose. Plant-derived volatile (essential oils, active monomer components) and non-volatile (polysaccharides, saponins, polyphenols and alkaloids) ingredients with hypoglycemic activity are reviewed with respect to their potency and mechanism of action as well as the experimental models used in this regard. It is expected that this review could provide a theoretical basis for the application of plant-derived hypoglycemic ingredients to defend against diabetes.

Key words: plant extracts; non-volatile substances; volatile substances; hypoglycemic; mechanism of action

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