食品科学 ›› 2022, Vol. 43 ›› Issue (15): 245-255.doi: 10.7506/spkx1002-6630-20210729-355

• 专题论述 • 上一篇    

G蛋白偶联雌激素受体在乳制品雌激素检测中的应用潜力

冯春雷,鲁丁强,庞广昌   

  1. (1.天津商业大学生物技术与食品科学学院,天津 300134;2.天津市食品生物技术重点实验室,天津 300134)
  • 发布日期:2022-08-30
  • 基金资助:
    国家自然科学基金面上项目(31671857);国家自然科学基金青年科学基金项目(31901782)

A Review of the Potential Application of G-protein Coupled Estrogen Receptor in Detection of Estrogen in Dairy Products

FENG Chunlei, LU Dingqiang, PANG Guangchang   

  1. (1. School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China; 2. Tianjin Key Laboratory of Food Biotechnology, Tianjin 300134, China)
  • Published:2022-08-30

摘要: 乳制品作为人们广泛消费的一种食品,其安全性备受关注。研究发现,乳制品中出现的高含量的天然雌激素和滥用或非法使用的合成雌激素可能导致人体内分泌失调,甚至诱发癌症。研究还发现,雌激素与G蛋白偶联雌激素受体(G-protein coupled estrogen receptor,GPER)互相作用来控制基于钙离子通道的快速非基因组途径,该途径有别于经典的核受体(雌激素受体(estrogen receptor,ER)α和ERβ)介导的基因组途径。本文阐述了GPER与雌激素以及乳制品中雌激素检测的关系,重点介绍了乳制品中雌激素生物学检测方法的研究进展,并对GPER在乳制品雌激素检测中的应用潜力进行了分析和展望。

关键词: 雌激素;乳制品;G蛋白偶联雌激素受体;雌激素受体;生物学检测;生物传感器

Abstract: As a widely consumed food, the safety of dairy products has gained much attention. Studies have found that high levels of natural estrogen and the abuse or illegal use of synthetic estrogen in dairy products may lead to endocrine disorders and even induce cancers. It has also been found that estrogen can interact with G-protein coupled estrogen receptors (GPER) to control a rapid non-genomic pathway based on calcium ion channels, which is distinct from the classical genomic pathway mediated by nuclear receptors (estrogen receptor (ER) α and ERβ). In this review, we describe the relationship between GPER and estrogen and estrogen detection in dairy products, with focus on recent progress in the biological methods for the detection of estrogen in dairy products. Furthermore, an outlook on the application potential of GPER in estrogen detection in dairy products is given.

Key words: estrogen; dairy products; G-protein coupled estrogen receptors; estrogen receptor; biological detection; biosensor

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