食品科学 ›› 2022, Vol. 43 ›› Issue (15): 302-311.doi: 10.7506/spkx1002-6630-20210730-359

• 专题论述 • 上一篇    

铁蛋白纳米载体在营养与健康领域的应用研究进展

刘博,张晨曦,臧佳辰,吕晨艳,张拓,赵广华   

  1. (1.中国农业大学食品科学与营养工程学院,北京 100083;2.中国农业大学食品功能胶体与软物质研究中心,北京 100083)
  • 发布日期:2022-08-30
  • 基金资助:
    “十三五”国家重点研发计划重点专项(2018YFD0901004);国家自然科学基金青年科学基金项目(31901638); 中央高校基本科研业务费专项资金项目(2021TC046)

Review of Ferritin Nanocarrier Applications in the Field of Nutrition and Health

LIU Bo, ZHANG Chenxi, ZANG Jiachen, LÜ Chenyan, ZHANG Tuo, ZHAO Guanghua   

  1. (1. College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; 2. Research Center of Functional Food Colloids and Soft Matter, China Agricultural University, Beijing 100083, China)
  • Published:2022-08-30

摘要: 铁蛋白由于其良好的水溶性和生物相容性以及可逆自组装特性,已被广泛应用于各种生物活性分子的包埋递送。利用固有的肿瘤靶向性,铁蛋白纳米空腔中装载药物分子或纳米颗粒则可用于癌症的监测、诊断与治疗等。科学家们也在通过重新设计构建铁蛋白纳米笼进而拓展铁蛋白的应用范围。本文将对天然及非天然铁蛋白分子的结构特点进行总结,并对其在营养成分包埋、重金属检测和生物医药领域的应用进展进行综述。

关键词: 铁蛋白;蛋白质纳米材料;物质包埋;靶向递送

Abstract: Due to its good water solubility, biocompatibility and reversible self-assembly property, ferritin has been widely used in the encapsulation and delivery of bioactive molecules. Benefiting from the inherent tumor-targeting feature, ferritin nanocavities loaded with drug molecules or nanoparticles can be used for cancer imaging, diagnosis and treatment. Scientists have made efforts to reconstruct ferritin nanocages to expanded the application of ferritin. In this paper, the structural characteristics of natural and manufactured ferritin molecules are summarized, and the recent progress in their application in the fields of bioactive molecule encapsulation, heavy metal detection and biomedicine is reviewed.

Key words: ferritin; protein nanomaterials; encapsulation; targeted delivery

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