二氢杨梅素固体自微乳的制备及表征

doi:10.7506/spkx1002-6630-20210905-053

食品科学 ›› 2022, Vol. 43 ›› Issue (16): 145-152.doi: 10.7506/spkx1002-6630-20210905-053

二氢杨梅素固体自微乳的制备及表征

黄娟，岳晶晶，冯璇，王立增，褚兰玲，解文静，张佳靓，吕奕文

（1.常熟理工学院生物与食品工程学院，江苏常熟 215500；2.南京林业大学轻工与食品学院，江苏南京 210037；3.宏胜饮料集团有限公司，浙江杭州 311200）

出版日期:2022-08-25 发布日期:2022-08-31
基金资助:
江苏省高等学校自然科学研究面上项目（20KJD550001）；苏州市农业科技创新-农业应用基础研究项目（SNG2021035）

Preparation and Characterization of Dihydromyricetin-Loaded Solid Self-Emulsifying Delivery System

HUANG Juan, YUE Jingjing, FENG Xuan, WANG Lizeng, CHU Lanling, XIE Wenjing, ZHANG Jiajing, LÜ Yiwen

(1. School of Biology and Food Engineering, Changshu Institute of Technology, Changshu 215500, China; 2. School of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, China; 3. Hongsheng Beverage Group Co. Ltd., Hangzhou 311200, China)

Online:2022-08-25 Published:2022-08-31

摘要/Abstract

摘要： 为改善二氢杨梅素的稳定性和溶解度、提高生物利用度，采用二氧化硅物理吸附的方式制备二氢杨梅素固体自微乳。二氧化硅和液体自微乳质量比≥0.6时，制备得到白色疏松粉末状的固体自微乳具有较好的流动性。制得的固体自微乳中二氢杨梅素质量分数为（0.30±0.03）%。X射线衍射分析与红外光谱分析显示，二氢杨梅素以无定形或溶解态存在于样品中，液体自微乳以物理吸附的形式吸附进二氧化硅孔洞。体外释放结果表明，液体和固体自微乳的释放时间延长，可持续释放8 h以上，二氧化硅在一定程度上抑制二氢杨梅素的释放，起到缓释作用。体外模拟胃肠消化表明，固体自微乳的主要消化部位在肠道。经模拟胃肠消化后，自微乳中二氢杨梅素的生物可给率由原料的34.01%提高到70%以上，表明自微乳可提高活性物的肠道吸收利用。液体自微乳固体化后二氢杨梅素的生物可给率出现一定程度的下降，这是由于液体自微乳不能及时从二氧化硅的孔穴中溶解释放，二氧化硅固体化可延长二氢杨梅素的消化吸收。固体自微乳可改善二氢杨梅素的化学稳定性。

关键词: 二氢杨梅素；固体自微乳；体外释放；模拟消化

Abstract: Dihydromyricetin-loaded solid self-emulsifying delivery system was prepared by the silica particle adsorption method to overcome the problem of the low stability, solubility and bioavailability of dihydromyricetin. When the mass ratio of silica particles to liquid self-emulsifying delivery system was larger than 0.6, a white loose powder was prepared, which had good flowability. The content of dihydromyricetin in the solid self-emulsifying delivery system was (0.30 ± 0.03)%. The X-ray diffraction and infrared spectral results revealed that dihydromyricetin existed in an amorphous or dissolved state in the sample, and that liquid self-emulsifying delivery system was physically adsorbed into the pores of silica. The in vitro release results showed that compared with an ethanol solution of dihydromyricetin, the release time of dihydromyricetin from the liquid and solid self-emulsifying delivery system was prolonged, and the sustained release lasted for more than 8 h. Silica particles inhibited the release of dihydromyricetin to a certain extent. The in vitro simulated digestion experiments showed that the solid self-emulsifying delivery system was mainly digested in the intestinal juice. After self-emulsification, the bioaccessibility of dihydromyricetin increased from about 34.01% to more than 70%, indicating that the self-emulsifying delivery system can improve the intestinal absorption and utilization of bioactive components. Since the liquid self-emulsifying delivery system could not be dissolved or released from the pores of silica particles in time, the bioaccessibility of dihydromyricetin decreased to a certain extent after the liquid self-emulsifying delivery system was solidified. The solidification of silica particles could prolong the digestion and absorption of dihydromyricetin. Moreover, the solid self-emulsifying delivery system could improve the chemical stability of dihydromyricetin.

Key words: dihydromyricetin; solid self-emulsifying delivery system; in vitro release; simulated digestion

中图分类号:

TS201.7

黄娟，岳晶晶，冯璇，王立增，褚兰玲，解文静，张佳靓，吕奕文. 二氢杨梅素固体自微乳的制备及表征[J]. 食品科学, 2022, 43(16): 145-152.

HUANG Juan, YUE Jingjing, FENG Xuan, WANG Lizeng, CHU Lanling, XIE Wenjing, ZHANG Jiajing, LÜ Yiwen. Preparation and Characterization of Dihydromyricetin-Loaded Solid Self-Emulsifying Delivery System[J]. FOOD SCIENCE, 2022, 43(16): 145-152.

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二氢杨梅素固体自微乳的制备及表征

Preparation and Characterization of Dihydromyricetin-Loaded Solid Self-Emulsifying Delivery System

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