食品科学 ›› 2024, Vol. 45 ›› Issue (5): 345-357.doi: 10.7506/spkx1002-6630-20230420-199

• 专题论述 • 上一篇    

食物过敏的膳食危险因素及其调控作用机制研究进展

孙佳晨,张巧智,李华韬,张岩,傅玲琳   

  1. (1.浙江工商大学食品与生物工程学院,浙江 杭州 310018;2.河北省食品检验研究院,河北省食品安全重点实验室,国家市场监管重点实验室(特殊食品监管技术),特殊食品安全与健康河北省工程研究中心,河北 石家庄 050000)
  • 出版日期:2024-03-15 发布日期:2024-04-03
  • 基金资助:
    浙江省自然科学基金重点项目(LZ23C200001);浙江省基础公益研究项目(LGN22C200027); 浙江省市场监督管理局“雏鹰计划”科技培育项目(CY2023005); 浙江省“三农九方”农业科技协作计划揭榜挂帅项目(2022SNJF078); 浙江工商大学“数字+”学科建设重大项目(SZJ2022A010)

Research Progress on Dietary Risk Factors and Regulatory Mechanisms of Food Allergy

SUN Jiachen, ZHANG Qiaozhi, LI Huatao, ZHANG Yan, FU Linglin   

  1. (1. School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China; 2. Hebei Food Inspection and Research Institute, Hebei Food Safety Key Laboratory, Key Laboratory of Special Food Supervision Technology for State Market Regulation, Hebei Engineering Research Center for Special Food Safety and Health, Shijiazhuang 050000, China)
  • Online:2024-03-15 Published:2024-04-03

摘要: 当前,食物过敏的发病率在全球范围内逐渐升高,食物过敏已经成为人们日益关注的食品安全和公共卫生问题。除遗传因素外,膳食因素是导致食物过敏风险升高的重要因素,而肠道菌群在膳食和免疫系统之间起着重要的中介作用。鉴于此,本文系统综述了近年来针对食物过敏膳食危险因素的相关研究,针对不同危险因素的免疫学作用机理、人群队列研究以及干预实验的结果进行了汇总,并对其中肠道菌群发挥的作用进行了深入探讨。本文可为食物过敏的预防和控制,以及以肠道菌群为靶点的食物过敏机制研究与调控策略提供借鉴和新思路。

关键词: 食物过敏;致敏原;膳食危险因素;肠黏膜免疫;肠道微生物

Abstract: At present, the incidence of food allergy is increasing worldwide. Food allergy has become a food safety and public health issue of growing concern. In addition to genetic factors, dietary factors are important factors causing increased risks of food allergy, and the intestinal microbiota plays an important mediating role between diet and the immune system. In view of this, this article systematically reviews recent studies on dietary risk factors for food allergy by summarizing the immunological mechanisms of action of different risk factors and the results of cohort studies and intervention experiments and by providing an in-depth discussion on the role of the intestinal flora in this regard. This review will provide references and new ideas for researchers to develop strategies for the prevention and control of food allergy, as well as understand the mechanism of food allergy using the intestinal microbiota as a target and develop regulatory strategies.

Key words: food allergy; allergen; food risk factors; intestinal mucosal immunity; intestinal microorganisms

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