关键词: 靶向蛋白质组学；食品安全；多反应监测；平行反应监测

Abstract: Food safety is a major global public health concern. Targeted proteomics based on mass spectrometry (MS) plays an increasingly important role in addressing this issue due to its high sensitivity, specificity, and quantitative accuracy. In this article, two common targeted proteomics approaches including multiple reaction monitoring (MRM) and parallel reaction monitoring (PRM) are briefly introduced. The progress that has been made in the application of targeted proteomics in food safety detection in the last five years is summarized including authentication of animal-derived foods, analysis of food allergens, and detection of foodborne pathogens and their toxins. Meanwhile, an outlook on the future development of this field is given.

Key words: targeted proteomics; food safety; multiple reaction monitoring; parallel reaction monitoring