食品科学 ›› 2026, Vol. 47 ›› Issue (5): 376-392.doi: 10.7506/spkx1002-6630-20250918-143

• 专题论述 • 上一篇    

不同酵母和酵母蛋白的生产与应用及蛋白合成调控规律研究进展

伍君权,匡小丽,刘传顺,薛亮,吴清平,杨美艳   

  1. (1.华南农业大学食品学院,广东 广州 510642;2.广东省科学院微生物研究所,华南应用微生物国家重点实验室,广东省微生物安全与健康重点实验室,国家卫生健康委员会微生物食品营养与安全科技创新平台,国家市场监督管理总局重点实验室(食品微生物安全大数据技术),国家卫生健康委员会食品安全风险评估与标准研制特色实验室,粤港澳大湾区微生物安全与健康国际科技创新中心,广东 广州 510070)
  • 发布日期:2026-04-13
  • 基金资助:
    国家食品营养与安全重点研发计划专项(2023YFF1104100)

Research Progress in the Production, Application and Regulatory Mechanisms of Yeast Proteins

WU Junquan, KUANG Xiaoli, LIU Chuanshun, XUE Liang, WU Qingping, YANG Meiyan   

  1. (1. College of Food Science, South China Agricultural University, Guangzhou 510642, China; 2. State Key Laboratory of Applied Microbiology in South China, Guangdong Key Laboratory of Microbial Safety and Health, Science and Technology Innovation Platform for Microbial Food Nutrition and Safety, National Health Commission, Key Laboratory (Big Data Technology for Food Microbial Safety) of State Administration for Market Regulation, Special Laboratory for Food Safety Risk Assessment and Standard Development of National Health Commission, International Science and Technology Innovation Center for Microbial Safety and Health of Guangdong-Hong Kong-Macao Greater Bay Area, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China)
  • Published:2026-04-13

摘要: 随着全球人口增长和传统蛋白来源面临的环境压力,酵母蛋白作为一种可持续的新型蛋白质来源受到广泛关注。酵母蛋白不仅营养价值高、环境友好,还在食品、饲料和生物制药等领域展现出广阔的应用前景。其生产过程涵盖发酵、细胞破壁、蛋白提取与纯化等关键技术,且可通过优化发酵条件和提取工艺显著提高产量和质量。不同酵母菌种,如酿酒酵母(Saccharomyces cerevisiae)、假丝酵母属(Candida spp.)、解脂耶氏酵母(Yarrowia lipolytica)和马克斯克鲁维酵母(Kluyveromyces marxianus)等,在多种底物上展现出不同的蛋白产量和质量,为工业化生产提供了丰富的选择。此外,酵母蛋白合成的调控规律涉及基因转录、翻译调控、氮代谢等多个层面,系统生物学技术在挖掘关键合成基因和调控元件方面发挥着重要作用。本文综述不同酵母及其蛋白的生产、应用和酵母蛋白合成调控规律的研究进展,展望其在未来可持续发展中的重要作用,为酵母蛋白的进一步研究和工业化应用提供了全面的理论基础。

关键词: 新型蛋白资源;酵母;酵母蛋白;生产与应用;蛋白合成调控

Abstract: With global population growth and increasing environmental pressures on traditional protein sources, yeast proteins have attracted much attention as a sustainable alternative. Yeast proteins are not only nutritionally valuable and environmentally friendly, but also show broad application prospects in the food, feed and biopharmaceutical fields. The production process covers key technologies such as fermentation, cell disruption, and protein extraction and purification, and the yield and quality of yeast proteins can be significantly improved by optimizing fermentation conditions and the extraction process. Different yeast species, such as Saccharomyces cerevisiae, Candida spp., Yarrowia lipolytica and Kluyveromyces marxianus, exhibit different protein yields and qualities on a variety of substrates, providing multiple options for industrial production. In addition, the regulation of yeast protein synthesis involves multiple levels, including gene transcription, translation regulation, and nitrogen metabolism. Systems biotechnology plays an important role in identifying key synthetic genes and regulatory elements. This review summarizes recent advances in the production and application of proteins from different yeasts, as well as the regulatory mechanisms underlying yeast protein synthesis. It also gives an outlook on the important role of yeast proteins in future sustainable development. This review provides a comprehensive theoretical basis for further research and industrial application of yeast proteins.

Key words: novel protein resources; yeast; yeast proteins; production and application; regulation of protein synthesis

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