金针菇多糖免疫调节机制及应用研究进展

doi:10.7506/spkx1002-6630-20251231-296

食品科学 ›› 2026, Vol. 47 ›› Issue (11): 379-389.doi: 10.7506/spkx1002-6630-20251231-296

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金针菇多糖免疫调节机制及应用研究进展

陈梦悦，曹雪颖，宋伟民，芦昶彤，陈什康，马常阳

（1.国家食用菌加工技术研发专业中心，河南开封 475004；2.河南大学农学院，河南郑州 450046；3.河南中烟工业有限责任公司，河南郑州 450000；4.河南省功能食品工程技术研究中心，河南开封 475004；5.河南省特殊食品校企研发中心，河南开封 475004；6.河南省药食两用资源功能研究国际联合实验室，河南开封 475004；7.河南省特色植物健康食品创新与制造重点实验室，河南开封 475004）

发布日期:2026-07-02
基金资助:
国家自然科学基金青年科学基金项目（32202055）；河南省科技创新人才发展计划项目（25HASTIT046）

Research Progress on Immunomodulatory Mechanisms and Applications of Flammulina velutipes Polysaccharides

CHEN Mengyue, CAO Xueying, SONG Weimin, LU Changtong, CHEN Shikang, MA Changyang

(1. National R&D Center for Edible Fungus Processing Technology, Kaifeng 475004, China; 2. College of Agriculture, Henan University, Zhengzhou 450046, China; 3. China Tobacco Henan Industrial Co. Ltd., Zhengzhou 450000, China; 4. Functional Food Engineering Technology Research Center in Henan Province, Kaifeng 475004, China; 5. Special Food University-Enterprise Research and Development Center in Henan Province, Kaifeng 475004, China; 6. International Joint Laboratory for Functional Research on Medicinal and Edible Resources in Henan Province, Kaifeng 475004, China; 7. Key Laboratory for Innovation and Manufacturing of Speciality Plant Health Food in Henan Province, Kaifeng 475004, China)

Published:2026-07-02

摘要/Abstract

摘要： 金针菇多糖（Flammulina velutipes polysaccharide，FVP）是金针菇的主要活性成分之一，具有良好的免疫调节、抗炎、抗氧化、抗肿瘤活性。本文系统梳理FVP的提取纯化工艺及其精细结构特征，重点剖析其在“免疫器官-免疫细胞-模式识别受体-信号通路-肠道微生态”五大维度的分子免疫机制。同时，深入探讨FVP的构效关系，并对其在食品、医药、日化及农业领域的应用潜力进行展望，旨在为FVP的高值化开发提供科学参考。

关键词: 金针菇；多糖；免疫调节；提取；纯化

Abstract: Flammulina velutipes polysaccharide (FVP), one of the major active components of F. velutipes, exhibit prominent immunomodulatory, anti-inflammatory, antioxidant, and antitumor activities. In this review, the extraction and purification processes of FVP as well as their fine structural characteristics are systematically summarized, and their molecular immunomodulatory mechanisms are analyzed with emphasis on five dimensions: immune organs, immune cells, pattern recognition receptors, signaling pathways, and intestinal microecology. Meanwhile, this review presents an in-depth discussion on the structure-activity relationship of FVP and an outlook on their application potentials in the fields of food, medicine, daily chemical products, and agriculture, aiming to provide scientific references for the valorization of FVP.

Key words: Flammulina velutipes; polysaccharide; immunomodulatory; extraction; purification

中图分类号:

TS201.2
Q539

陈梦悦，曹雪颖，宋伟民，芦昶彤，陈什康，马常阳. 金针菇多糖免疫调节机制及应用研究进展[J]. 食品科学, 2026, 47(11): 379-389 https://doi.org/10.7506/spkx1002-6630-20251231-296

CHEN Mengyue, CAO Xueying, SONG Weimin, LU Changtong, CHEN Shikang, MA Changyang. Research Progress on Immunomodulatory Mechanisms and Applications of Flammulina velutipes Polysaccharides[J]. FOOD SCIENCE, 2026, 47(11): 379-389 https://doi.org/10.7506/spkx1002-6630-20251231-296

金针菇多糖免疫调节机制及应用研究进展

Research Progress on Immunomodulatory Mechanisms and Applications of Flammulina velutipes Polysaccharides

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