关键词: 芹菜汁, 肾血管性高血压大鼠, 血压, 血管张力

Abstract: Objectives: The effects of celery juice on the SBP(systolic blood pressure) of RHR (renovascular hypertensive rats) and on the tension of the rat aortic rings were studied. Methods and Results: ① 60.3±18.1g/kg bw and 123.5±28.1g/kg bw celery juices were respectively administrated to RHR and SBP, the heart rates and body weight of rats were assayed once a week. After 6 weeks, compared with control group, the SBP of rats administrated different celery doses all decrease (p<0.05). ② Celery juice caused relaxation in rat aortic rings precontract with NE(norepinephrine) (3.0×10-7mol/L). By adding celery juice in advance, cumulative concentration-response points of rat aortic rings shift downward by CaCl2 and NE(p<0.05) while the points show no change by KCl (p>0.05). ③ In rat aortic rings, compared with that at 37℃, the relaxation extent of the rings heated at 70℃ for 20min does not change (p>0.05); however, when the rings were heated at 100℃ for 3min, the relaxation extent weakens significantly (p<0.05). Conclusion: Celery juice can decrease the SBP of RHR and relax the rat aortic rings. And its vasodilatory mechanism may possibly inhibit the receptor operated channel (ROC) in smooth muscle. Hypotensive ingredi- ents of celery juice are heat-resistant to some extent and heating the rat aortic rings at 70℃ for 20min can not affect its vasodilatory fuction while that weakens significantly at 100℃ for 3min.

Key words: celery juice, renovascular hypertensive rat, SBP(systolic blood pressure), vascular tension