响应面法优化油酰海藻酸酯的合成工艺

doi:10.7506/spkx1002-6630-201110002

食品科学 ›› 2011, Vol. 32 ›› Issue (10): 6-11.doi: 10.7506/spkx1002-6630-201110002

响应面法优化油酰海藻酸酯的合成工艺

李倩，刘晨光*

中国海洋大学海洋生命学院

出版日期:2011-05-25 发布日期:2011-04-08
基金资助:
国家“863”计划项目(2007AA10Z349)

Optimization of Synthesis Process for Oleoyl-alginate Ester by Response Surface Methodology

LI Qian，LIU Chen-guang*

College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China

Online:2011-05-25 Published:2011-04-08

摘要/Abstract

摘要： 采用响应面法分析不同因素对油酰海藻酸酯合成工艺的影响。选择甲酸用量、油酰氯用量、反应温度和反应时间4个因素，采用响应面分析法，根据Box-Behnken组合设计原理设计试验。结果表明：最适条件为海藻酸量0.5g、4.95mL甲酸、11.27mL油酰氯、反应温度50℃、反应时间20min。在此条件下，取代度可达4.93%、产率可达92.27%，与方程的预测值相符。

关键词: 油酰海藻酸酯（OAE）, 响应面法（RSM）, 合成工艺

Abstract: Box-Behnken experimental design and response surface methodology (RSM) were combinedly employed to evaluate the effects of the amounts of formic acid and oleoyl chloride as well as reaction temperature and time on the synthesis of oleoyl-alginate ester (OAE). The optimum synthesis conditions of OAE were found to be alginate amount of 0.5 g, formic acid amount of 4.95 mL, oleoyl chloride amount of 11.27 mL, reaction temperature of 50 ℃ and reaction time of 20 min. Under these conditions, the maximum degree of substitution (DS) and yield of OAE were observed to be respectively 4.93% and 92.27%, which were in accordance with the corresponding predicted values.

Key words: oleoyl-alginate ester (OAE), response surface methodology (RSM), synthesis process

中图分类号:

TS236.9

李倩，刘晨光. 响应面法优化油酰海藻酸酯的合成工艺[J]. 食品科学, 2011, 32(10): 6-11.

LI Qian，LIU Chen-guang. Optimization of Synthesis Process for Oleoyl-alginate Ester by Response Surface Methodology[J]. FOOD SCIENCE, 2011, 32(10): 6-11.

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响应面法优化油酰海藻酸酯的合成工艺

Optimization of Synthesis Process for Oleoyl-alginate Ester by Response Surface Methodology

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