食品科学 ›› 2012, Vol. 33 ›› Issue (1): 248-251.

• 营养卫生 • 上一篇    下一篇

金花葵黄酮对高脂血症大鼠血脂的影响

李 芸1,杨秀松2,何计国1,*   

  1. 1. 中国农业大学食品科学与营养工程学院 2. 国家食品药品监督管理局培训中心
  • 收稿日期:2011-03-22 修回日期:2012-01-05 出版日期:2012-01-15 发布日期:2012-01-12
  • 通讯作者: 李芸 E-mail:shirley8624@sohu.com

Effect of Abelmoschus manihot Flavonoids on Blood Lipid Levels of Hyperlipidemic Rats

  • Received:2011-03-22 Revised:2012-01-05 Online:2012-01-15 Published:2012-01-12

摘要: 目的:探讨金花葵黄酮对高脂血症模型大鼠血脂的影响。方法:100只SD大鼠,按体质量随机分为6组;除空白对照组外,其余各组饲喂高脂饲料制作动物高脂血症模型;其中金花葵黄酮分为3、30、90mg/(kg·d)剂量组;阳性对照组灌胃洛伐他汀片10mg/(kg·d);空白对照组、阴性对照组灌胃10mL/(kg·d)蒸馏水,连续6周。每两周测定血脂相关指标,最后一周测定氧化型低密度脂蛋白(ox-LDL)。结果:3个剂量组大鼠血清血脂水平(总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C))及ox-LDL明显降低。结论:金花葵黄酮能缓解大鼠高脂血症,降低ox-LDL水平,延缓泡沫细胞的形成和动脉粥样硬化的发生。

关键词: 金花葵, 黄酮, 高脂血症

Abstract: Objective: To explore the effect of Abelmoschus manihot flavonoids on blood lipids of hyperlipidemic rats. Methods: Totally 100 SD rats were divided randomly into 6 groups: normal control group, high-fat control group, lovastatin positive control group at the dose of 10 mg/(kg·d), and flavonoid groups at low, middle and high doses (3, 30 mg/(kg·d) and 90 mg/(kg·d)). Except normal the control group, all groups were fed high-fat diet to establish a hyperlipidemia model. Normal control group and high-fat control group were given distilled water at the dose of 10 ml/(kg·d) once a day for 6 consecutive weeks. Serum TC, TG, HDL-C, LDL-C, and ox-LDL were determined after the last administration. Results: Compared with the control group, serum TC, TG, LDL-C and ox-LDL revealed a significantly reduction in all the model groups. However, no significant difference in HDL-C level was observed among these groups. Conclusion: The flavonoids can delay the formation and development of arteriosclerosis.

Key words: Abelmoschus manihot, flavonoids, hyperlipidemia

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