饮食中的脂肪酸对孕妇及其子代的作用研究进展

摘要/Abstract

摘要： 妊娠期期间的饮食对母体和胎儿的健康都具有重要作用。脂肪酸作为人们日常饮食必不可少的成分，对人类健康的影响作用已日益凸显。孕妇脂肪酸的不科学摄入，不仅会损害自身健康，还对胎儿的发育，甚至其表观遗传产生不利影响。越来越多的研究证明，体内大量游离脂肪酸和ω-6脂肪酸会诱导炎症反应的发生，而ω-3脂肪酸的抗炎活性可以平衡体内的免疫状态。本文从脂肪酸体内代谢、免疫活性对妊娠期母体和胎儿的免疫状态、表观遗传方面的作用进行论述，为孕妇科学摄入脂肪酸提供指导意见。

关键词: 脂肪酸, 孕妇, 胎儿, 免疫

Abstract: During the period of pregnancy which is very special in life, the diet is very important for maternal and fetal health. As an essential composition for daily diet, fatty acids have an effect on health, which has become increasingly prominent. Unscientific intake of fatty acids by pregnant women will not only damage their own health, but also have adverse influence on fetal development or even epigenetics. A growing number of studies have showed that the over-does free fatty acids and ω-6 fatty acids can induce the inflammatory response in vivo, while anti-inflammatory activity of ω-3 fatty acids can balance the response in vivo. The effect of fatty acids metabolism, immune activity on maternal and fetal immune status and epigenetics are discussed in this review. Advices about scientific intake of fatty acids for pregnant women are also provided at the end of this article.

Key words: fatty acids, pregnant women, infant, immune

中图分类号:

R155.1

耿超宇，庞广昌*. 饮食中的脂肪酸对孕妇及其子代的作用研究进展[J]. 食品科学, 2012, 33(19): 315-320.

Chao-Yu GENG Pang guangchang. A Review of the Effects of Dietary Fatty Acids on the Health of Pregnant Women and Offspring[J]. FOOD SCIENCE, 2012, 33(19): 315-320.

参考文献

[1] SETJI T L, BROWN A J, FEINGLOS M N. Gestational diabetes mellitus[J]. Clinical Diabetes, 2005, 23(1): 17-24.
[2] SINGH S K, RASTOGI A. Gestational diabetes mellitus[J]. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 2008, 2: 227-234.
[3] SESHIAH V, BALAJI V, GREEN A, et al. Gestational diabetes mellitus in India. JAPI, 2004, 52: 707-711.
[4] 李嫒. 妊娠期糖尿病的研究进展[J]. 中国城乡企业卫生, 2012, 148: 115-117.
[5] 金蓉, 程海东. 妊娠期糖代谢变化与巨大儿的相关性分析[J]. 实用妇产科杂志, 2006, 22(4): 239-241.
[6] JONES C W. Gestational diabetes and its impact on the neonate[J]. Neonatal Network, 2001, 20(6): 17-23.
[7] 庄依亮, 李笑天. 病理产科学[M]. 北京: 人民卫生出版社, 2007: 450.
[8] 张丽丽, 黄丽娟. 自由脂肪酸对妊娠期胰岛素抵抗的影响作用[J]. 现代妇产科进展, 2007, 16(6): 464-466.
[9] KOVACS P, STUMVOLL M. Fatty acids and insulin resistance in muscle and liver[J]. Best Practice and Research Clinical Endoucrinology and Metabolism, 2005, 19(4): 625-635.
[10] MELNIK B C. Permanent impairment of insulin resistance from pregnancy to adulthood: The primary basic risk factor of chronic Western diseases[J]. Medical Hypotheses, 2009, 73: 670-681.
[11] HADAEGH F, TOHIDI M, HARATI H, et al. Prevalence of gestational diabetes mellitus in southern Iran[J]. Endocrinol Practse, 2005, 11: 313-318.
[12] 于江, 王炎. 妊娠期糖尿病患者血清瘦素肿瘤坏死因子与胰岛素抵抗的关系[J]. 中国实用妇科与产科杂志, 2005, 21(10): 623-624.
[13] FERNANDES F S, SARDINHA F L, CARULLA P, et al. Dietary lipids during early pregnancy differently influence adipose tissue metabolism and fatty acid composition in pregnant rats with repercussions on pup’s development[J]. PLEFA, 2012, 86: 167-174.
[14] YI D, ZENG S, GUO Y. A diet rich in n-3 polyunsaturated fatty acids reduced prostaglandin biosynthesis, ovulation rate, and litter size in mice[J]. Theriogenology, 2012, 78: 28-38.
[15] MATORRAS R, RERTEAGUDO L, SANJURJO P, et al. Intake of long chain w3 polyunsturated fatty acids during pregnancy and the influence of levels in the mother on newborn levels[J]. Obstetrics and Gynecology, 1999, 83: 179-184.
[16] HERRERA E. Lipid metabolism in pregnancy and its consequences in the fetus and newborn[J]. Endorine, 2002, 19: 43-45.
[17] RAMOS M P, CAMPO S, HERRERA E. Fat accumulation in the rat during early pregnancy is modulated by enhanced insulin responsiveness[J]. Physiological Endocrinol Metabolism, 2003, 285: 318-328.
[18] VILLAR J, COGSWELL E, CASTILLO P, et al. Effect of fat and fat-free mass deposition during pregnancy on brith weight[J]. Obstetrics and Gynecology, 1992, 167: 1344-1352.
[19] HERRERA E, SENOLILLA H O. Materal lipid metabolism during normal pregnancy and its implications to fetal development[J]. Clinical Lipidology, 2010, 5: 899-911.
[20] INNIS S M. Dietary n-3 fatty acids and brain development[J]. Nutrition, 2007, 137(4): 855-859.
[21] KOLETZKO B,LARQUE E,DEMMELMAIR H. Placental transfer of long-chain polyunsaturated fatty acids[J]. Journal of Perinatal Medicine, 2007, 35:S5-11.
[22] LARQUE E, DEMMELMAIR H,BERGER B, et al. In vivo investigation of the placental transfer of 13C-labeled fatty acids in humans[J]. Lipid Research, 2003, 44: 49–55.
[23] TOBIN K A R, STAFF G M, DUTTAROY A K, et al. Long-chain polyunsaturated fatty acid transport across human placental choriocarcinoma (BeWo) cells[J]. Placenta, 2009, 30: 41-47.
[24] ZECHNER R, ZIMMERMANN R, EICHMANN T O, et al. Fat signals-lipases and lipolysis in lipid metabolism and signaling[J]. Cell Metabolism, 2012, 15(3): 279-291.
[25] COHEN J C, HORTON J D, HOBBS H H. Human fatty liver disease :old questions and new insights[J]. Science, 2011, 332(6037): 1519-1523.
[26] UNGER R H, CLARK G O, SCHERER P E, et al. Lipid homeo stasis,lipotoxicity and the metabolic syndrome[J]. Biochim Bio phys Acta, 2010, 1801(3), 209–214.
[27] SUMMERS S A. (2010). Sphingolipids and insulin resistance: the five Ws[J]. Current Opinion in Lipidology, 2010, 21(2): 128–135.
[28] CAlDER P C. n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases[J]. Clinical Nutrition, 2006, 83(6): 1505–1519.
[29] SPECTOR A. Essentiality of fatty acids[J]. Lipids, 1999, 34: S1–S3.
[30] SIMOPOULOS A P. Omega-3 fatty acids in health and disease and in growth and development[J]. Clinical Nutrition 1991, 54(3): 438–63.
[31] 应豪, 王德芬. 膳食脂肪对妊娠期糖尿病孕妇发病的影响[J]. 中华妇产科杂志, 2006, 41(11): 729-731.
[32] KIM W, KHAN N A, MCMURRAY D N, et al. Regulatory activity of polyunsaturated fatty acids in T-cell signaling[J]. Progress in Lipid Research, 2010, 49: 250-261.
[33] GALARRAGA B, HO M, YOUSSEF H M, et al. Cod liver oil (n -3 fatty acids) as an non-steroidal anti-inflammatory drug sparing agent in rheumatoid arthritis[J]. Rheumatology, 2008, 47(5): 665–669.
[34] MIZOTA T, FUJITA-KAMBARA C, MATSUYA N, et al. Effect of dietary fatty acid composition on Th1/Th2 polarization in lymphocytes[J]. Parenter Enteral Nutrition: 2009, 33(4): 390–396.
[35] ZHANG Ping, Smith R, CHAPKIN R S, et al. Dietary (n-3) polyunsaturated fatty acids modulate murine Th1/Th2 balance toward the Th2 pole by suppression of Th1 development[J]. Nutrition, 2005, 135(7): 1745–1751.
[36] AIRES V, HICHAIM A, MOUTAIROU K,et al. Docosahexaenoic acid and other fatty acids induce a decrease in pHi in Jurkat T-cells[J]. British Journal of Pharmacology, 2003, 140(7): 1217–1226.
[37] 许青. 妊娠期糖尿病患者脂联素水平与胰岛素抵抗的关系[J]. 海峡药学, 2012, 24(4): 160-161.
[38] 田明, 吴连方. 妊娠期糖尿病孕妇并发妊娠期高血压疾病的临床特点及血清CRP、IL-6、TNF-α的水平分析[J]. 中国妇幼保健, 2012, 27: 1318-1321.
[39] 袁宏涛. 脂肪细胞因子与妊娠期糖尿病的研究进展[J]. 中国优生与遗传杂志, 2012, 20(4): 134-135.
[40] SABIO G, DAS M, MORA A, et al. A stress signaling pathway in adipose tissue regulates hepatic insulin resistannce[J]. Science, 2008, 322: 1539-1543.
[41] CALDER P C. Polyunsaturated fatty acids and inflammatory processes: New twists in an old tale[J]. Biochimie, 2009, 91:791-795.
[42] HOLZER R G, PARK E-J, LI Ning, et al. Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation[J]. Cell, 2011, 147(1): 173-184.
[43] 管淑梅, 王静. 瘦素脂联素与妊娠期糖尿病胰岛素抵抗关系的研究[J]. 中国优生与遗传杂志, 2011, 19(9): 81-82.
[44] KARNIK S K, CHEN Hainan, MCLEAM G W, et al. Menin controls growth of pancreatic β-cell in pregnant mice and promotes gestational diabetes mellitus[J]. Science, 2007, 318: 806-809.
[45] PARSONS T J, POWER C, MANOR O. Fetal and early life growth and body mass index from birth to early adulthood in 1958 British cohort: longitudinal study[J]. BMJ, 2001, 323: 1331-1335.
[46] WHITAKER R. Predicting preschooler obesity at brith: the role of maternal obesity in early pregnany[J]. Pediatrics, 2004, 114: 29-36.
[47] ZHANG S, RATTANATRAY L, MCMILLEN I C, et al. Periconptional nutrition and the early programming of a life of obesity or adversity[J]. Progress in Biophsics and Molecular Biology, 2011, 106(1): 307-314.
[48] CHALLIER J C, BASU S,BINTEIN T,et al. Obesity in pregnany stimulates macrophage accimulation and inflammation in the placenta[J]. Placenta, 2008, 29: 274-281.
[49] YAN Xu, ZHU M J, TONG J F, et al. Up-regulation of Toll-like receptor 4/nuclear factor kappaB signaling is associated with enhanced adipogenesis and insulin resistance in fetal skeletal muscle of obese sheep at late gestation[J]. Endocrinology, 2009, 151: 380-387.
[50] SCHAIFF W T, KNAPP J F, BARAK Y, et al. Ligand-activated peroxisome proliferator activated receptor gamma alters placental morphology and placental fatty acids uptake in mice[J]. Endocrinalogy, 2007, 148: 3625-3634.
[51] RICE G E, WONG M H, FARRUGIA W, et al. Contribution of type Ⅱphospholipse A2 to in vitro phopholipse A2 enzymatic activity in human term placenta[J]. Endocrinol, 1998, 157: 25-31.
[52] ZHU M J, DU M, NATHANIELSZ P W, et al. Maternal obesity up-regulates inflammatory signaling pathway and enhances cytokine expression in the mid-gestation sheep placenta[J]. Placenta, 2010, 31: 387-391.
[53] REYNA S M, GHOSH S, TANTIWONG P, et al. Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects[J]. Diabetes, 2008, 57: 2595-2602.
[54] SCHAEFFLER A, GROSS P, BUETTNER R, et al. Fatty acid-induced induction of Toll-like receptor 4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity[J]. Immunology, 2009, 126: 233-245.
[55] JONAKAIT G M. The effect of maternal inflammation on neuronal development:possible mechanisms[J]. International Journal of Developmental Neuroscience, 2007, 25: 415-425.
[56] CHILD C E, ROMIJN T, ENKE U, et al. Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters[J]. PLEFA, 2010, 83: 179-184.
[57] HALL J A, JHA S, SKINNER M M, et al. Maternal dietary n-3 fatty acids alter immune cell fatty acid composition and leukotriene production in growing chicks[J]. PLEFA, 2007, 76: 19-28.
[58] 钟燕芳, 薛素华, 麦明琴, 等. 人体必需脂肪酸在治疗胎儿宫内发育迟缓中的研究[J]. 中国优生与遗传杂志, 2010, 18(4): 88.
[59] HERRERA B M, KEILDSON S, LINDGREN C M. Genetics and epigenetics of obesity[J]. Maturitas, 2011, 69(1): 41-49.
[60] LEBARON M J, RASOULPOUR R J, KLAPACZ J, et al. Epigenetics and chenical safety assessment[J]. Mutation Research, 2010, 705: 83-95.
[61] BERGHE W V, NDLOVU M N, HOYA-ARIAS Ruben, et al. Keeping up NF-κB appearances: Epigenetic control of immunity or inflammation-triggered epigenetics[J]. Biochemical Pharmacology, 2006, 72: 1114-1131.
[62] JUNYENT M, PARNELL L D, LAI C Q, et al. ADAM17_i33708A > G polymorphism interacts with dietary n -6 polyunsaturated fatty acids to modulate obesity risk in the Genetics of Lipid Lowering Drugs and Diet Network study[J]. Nutrition, Metabolism and Cardiovascular Diseases, 2010, 20: 698-705.