白藜芦醇对多柔比星引起的心脏毒性保护作用研究进展

doi:10.7506/spkx1002-6630-20200115-186

食品科学 ›› 2021, Vol. 42 ›› Issue (5): 271-277.doi: 10.7506/spkx1002-6630-20200115-186

白藜芦醇对多柔比星引起的心脏毒性保护作用研究进展

吴文英，李文娟，李露，尹术华，赵文辉，姚于飞

（1.南昌大学食品科学与技术国家重点实验室，江西南昌 330047；2.江西中医药大学附属医院，江西南昌 330006）

出版日期:2021-03-15 发布日期:2021-03-29
基金资助:
国家自然科学基金地区科学基金项目（81860713）

Recent Advances in Research on the Cardioprotective Effect of Resveratrol on Doxorubicin-induced Cardiotoxicity

WU Wenying, LI Wenjuan, LI Lu, YIN Shuhua, ZHAO Wenhui, YAO Yufei

(1. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China; 2. The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China)

Online:2021-03-15 Published:2021-03-29

摘要/Abstract

摘要： 近年来，天然来源的生物活性物质备受消费者青睐。天然产物，尤其是食源性活性成分，作为对人体某种或多种机能有益的功能成分，与维持生命所需的多种生理功能密切相关，已成为当代社会营养保健和健康管理的选择趋势。抗肿瘤药物多柔比星介导的心肌损伤是其临床中较为常见的毒副作用，且所涉及心肌损伤机制错综复杂，限制了其在临床上的应用。白藜芦醇存在于花生、葡萄、虎杖和桑葚等多种植物和水果之中，心肌保护作用较为显著。白藜芦醇与多柔比星联合使用可预防多柔比星诱导的心脏毒性。本文主要综述了白藜芦醇对多柔比星引起的心脏毒性保护作用的相关研究进展，旨在为防治多柔比星引起的心脏毒性提供参考。

关键词: 多柔比星；心脏毒性；心肌保护；白藜芦醇

Abstract: Recently, naturally bioactive components have been increasingly favored by consumers due to their health benefits. In modern society, selection of naturally bioactive components especially food-borne bioactive ingredients, which are beneficial for one or more human body functions and closely related to many physiological functions essential to maintain life, for nutritional health care and health management has become a trend. Cardiac injury is a common toxic-side effect of the antitumor agent doxorubicin (DOX), and the underlying mechanism is complicated, limiting the clinical application of DOX. Fortunately, resveratrol, widely present in plants, such as peanut, grape, knotweed and mulberry, has potent cardioprotective effects. Moreover, resveratrol can prevent DOX from exerting its cardiotoxicity when they are applied together. Herein, recent advances in the cardioprotective effect of resveratrol against DOX-induced cardiotoxicity are reviewed, which will provide reference for the prevention and attenuation of DOX-induced cardiotoxicity.

Key words: doxorubicin; cardiotoxicity; cardioprotection; resveratrol

中图分类号:

TS201.4

吴文英，李文娟，李露，尹术华，赵文辉，姚于飞. 白藜芦醇对多柔比星引起的心脏毒性保护作用研究进展[J]. 食品科学, 2021, 42(5): 271-277.

WU Wenying, LI Wenjuan, LI Lu, YIN Shuhua, ZHAO Wenhui, YAO Yufei. Recent Advances in Research on the Cardioprotective Effect of Resveratrol on Doxorubicin-induced Cardiotoxicity[J]. FOOD SCIENCE, 2021, 42(5): 271-277.

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白藜芦醇对多柔比星引起的心脏毒性保护作用研究进展

Recent Advances in Research on the Cardioprotective Effect of Resveratrol on Doxorubicin-induced Cardiotoxicity

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