基质结构对纳米结构脂质载体中叶黄素生物利用度的调控机制

doi:10.7506/spkx1002-6630-20210421-300

食品科学 ›› 2022, Vol. 43 ›› Issue (12): 130-132.doi: 10.7506/spkx1002-6630-20210421-300

• 食品化学 • 上一篇

基质结构对纳米结构脂质载体中叶黄素生物利用度的调控机制

李新甜，徐亚元，张钟元，戴竹青，冯蕾，聂梅梅，李大婧，张国栋，张兴

（1.江苏省农业科学院农产品加工研究所，江苏南京 210014；2.南京农业大学食品科技学院，江苏南京 210095；3.江苏艾兰得营养品有限公司，江苏泰州 214504）

发布日期:2022-07-01
基金资助:
江苏省重点研发计划项目（BE2020333）；江苏省自然科学基金青年基金项目（SBK20180307）

Regulatory Effect of Matrix Structures on Bioaccessibility of Lutein Loaded into Nanostructured Lipid Carriers

LI Xintian, XU Yayuan, ZHANG Zhongyuan, DAI Zhuqing, FENG Lei, NIE Meimei, LI Dajing, ZHANG Guodong, ZHANG Xing

(1. Institute of Agro-product Processing, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China;2. College of Food and Technology, Nanjing Agricultural University, Nanjing 210095, China;3. Jiangsu Aland Nutrition Co. Ltd., Taizhou 214504, China)

Published:2022-07-01

摘要/Abstract

摘要： 通过分析不同基质结构叶黄素纳米结构脂质载体（lutein-loaded nanostructured lipid carriers，Lutein-NLCs）的晶体热力学特性、固化层厚度等结晶行为的变化，探究基质结构通过结晶行为对Lutein-NLCs中脂质消化、叶黄素释放、胶束形成过程以及叶黄素生物可给率的影响。结果显示：随着亚麻籽油质量分数增加，Lutein-NLCs的熔点和焓值先增加后降低，Lutein-NLCs的固化层厚度逐渐降低；当亚麻籽油质量分数低于90%时，随着亚麻籽油质量分数增加，Lutein-NLCs的脂质水解率、游离脂肪酸（free fatty acids，FFAs）和甘油一酯（monoacylglycerols，MAGs）释放率、叶黄素生物可给率均逐渐降低；4 种基质结构Lutein-NLCs的MAGs、FFAs水解速率和程度与其胶束化的速率和程度呈正相关；当亚麻籽油质量分数高于10%时，Lutein-NLCs的叶黄素释放速率与甘油三酯水解速率呈负相关，叶黄素胶束化速率与MAGs、FFAs胶束化速率呈负相关，与叶黄素释放速率呈正相关，并且叶黄素生物可给率与叶黄素释放率呈正相关。

关键词: 叶黄素；纳米结构脂质载体；基质结构；释放特性；生物利用度

Abstract: In this study, the effects of matrix structures on the crystal thermodynamic properties and solidified layer thickness of lutein-loaded nanostructured lipid carriers as well as lipid digestibility, lutein release, micelle formation and lutein bioaccessibility in Lutein-NLCs were investigated. The results showed that as the concentration of linseed oil increased, the melting point and enthalpy value of Lutein-NLCs first increased and then decreased, and the thickness of the solidified layer gradually decreased. The degree of lipid hydrolysis, the release of free fatty acids (FFAs) and monoacylglycerols (MAGs), and the bioaccessibility of lutein gradually decreased with increasing concentration of linseed oil up to 90%. The rate and extent of hydrolysis of MAGs and FFAs in Lutein-NLCs with four different matrix structures were positively correlated with their rate and extent of micellization. The release rate of lutein from Lutein-NLCs with linseed oil concentration higher than 10% was negatively correlated with the hydrolysis rate of TAGs. The micellization rate of lutein was negatively correlated with those of MAGs and FFAs, and was positively correlated with lutein release rate. The bioaccessibility of lutein was positively correlated with its release degree.

Key words: lutein; nanostructured lipid carriers; matrix structures; release properties; bioavailability

中图分类号:

TS201.2

李新甜，徐亚元，张钟元，戴竹青，冯蕾，聂梅梅，李大婧，张国栋，张兴. 基质结构对纳米结构脂质载体中叶黄素生物利用度的调控机制[J]. 食品科学, 2022, 43(12): 130-132.

LI Xintian, XU Yayuan, ZHANG Zhongyuan, DAI Zhuqing, FENG Lei, NIE Meimei, LI Dajing, ZHANG Guodong, ZHANG Xing. Regulatory Effect of Matrix Structures on Bioaccessibility of Lutein Loaded into Nanostructured Lipid Carriers[J]. FOOD SCIENCE, 2022, 43(12): 130-132.

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基质结构对纳米结构脂质载体中叶黄素生物利用度的调控机制

Regulatory Effect of Matrix Structures on Bioaccessibility of Lutein Loaded into Nanostructured Lipid Carriers

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