食品科学 ›› 2025, Vol. 46 ›› Issue (11): 333-342.doi: 10.7506/spkx1002-6630-20241121-161

• 专题论述 • 上一篇    

药食同源植物中干预糖尿病的活性物质研究进展

周怡霞,覃璐琪,刁娆,郑佳欢,刘佳萌,范蓓   

  1. (中国农业科学院农产品加工研究所/农业农村部农产品质量安全收贮运管控重点实验室,北京 100193)
  • 发布日期:2025-05-14
  • 基金资助:
    “十四五”国家重点研发计划重点专项(2022YFD1600303); 中国农业科学院科技创新工程项目(CAAS-ASTIP-2025-IFST-06)

Research Progress in Bioactive Compounds in Medicine Food Homologous Plants for Intervention in Diabetes

ZHOU Yixia, QIN Luqi, DIAO Rao, ZHENG Jiahuan, LIU Jiameng, FAN Bei   

  1. (Institute of Food Science & Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-products Quality and Safety in Harvest, Storage, Transportation, Management and Control, Ministry of Agriculture and Rural Affairs, Beijing 100193, China)
  • Published:2025-05-14

摘要: 糖尿病是一种由胰岛β细胞功能障碍和胰岛素抵抗引起的慢性进行性全身性疾病,其主要症状是血糖浓度升高。药食同源植物中含有多种降血糖活性成分,包括多糖类、多酚类、生物碱类、皂苷类、蛋白质与氨基酸等非挥发性物质及植物精油等挥发性物质,不良反应小,在预防和治疗糖尿病中发挥了重要作用。将富含降血糖活性成分的药食同源植物及其提取物复配应用到调味、饮料、糕点等食品中,作为预防和干预糖尿病的日常膳食补充剂,可在一定程度上缓解高血糖症状。本文总结近10 年来药食同源植物中降血糖活性成分分析鉴定、活性研究、临床应用及其在食品中的应用,为推动新的降血糖活性化合物挖掘鉴定并开发具有降血糖活性的功能食品提供理论依据。

关键词: 药食同源植物;降血糖活性;降糖机制;结构鉴定;应用

Abstract: Diabetes mellitus (DM) is a chronic, progressive systemic disease characterized by pancreatic β-cell dysfunction and insulin resistance. The primary symptom of this disease is elevated blood glucose levels. Medicine food homologous plants (MFP) contain a variety of hypoglycemic ingredients, including non-volatile substances (polysaccharides, polyphenols, alkaloids, saponins, proteins and amino acids) and volatile substances such as plant essential oils. These ingredients exhibit minimal adverse effects and play an important role in preventing and treating diabetes. The incorporation of combinations of MFP or their extracts rich in hypoglycemic ingredients into seasonings, beverages, pastries and other foods as daily dietary supplements holds promising potential for alleviating the symptoms of hyperglycemia. This review summarizes the progress that has been made in the identification, evaluation, clinical and food applications of hypoglycemic ingredients in MFP over the past decade, aiming to provide a theoretical basis for the exploration and identification of new hypoglycemic agents and for the development of functional foods with hypoglycemic properties.

Key words: medicine food homologous plants; hypoglycemic activity; hypoglycemic mechanism; structural characterization; application

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