食品科学 ›› 2025, Vol. 46 ›› Issue (14): 387-396.doi: 10.7506/spkx1002-6630-20241118-137

• 专题论述 • 上一篇    

谷氨酰胺肽的制备、结构解析及生理功能研究进展

林璐璐,郑丽萍,孟甘露,刘文颖,陈亮,张新雪   

  1. (中国食品发酵工业研究院有限公司,北京市蛋白功能肽工程技术研究中心,北京 100015)
  • 发布日期:2025-06-20
  • 基金资助:
    中国轻工业集团有限公司科技创新基金项目(ZQ2023JC-GC02)

Research Progress on the Preparation, Structural Analysis and Physiological Functions of Glutamine Peptides

LIN Lulu, ZHENG Liping, MENG Ganlu, LIU Wenying, CHEN Liang, ZHANG Xinxue   

  1. (Beijing Engineering Research Center of Protein and Functional Peptides, China National Research Institute of Food & Fermentation Industries Co., Ltd., Beijing 100015, China)
  • Published:2025-06-20

摘要: 谷氨酰胺肽(glutamine peptides,Gln peptides)是指非N端含有谷氨酰胺(glutamine,Gln)单体的生物活性肽,主要来源于小麦、玉米等植物蛋白,具有稳定性强、易消化及多种生物活性。近年来,其开发和应用备受国内外学者的关注。本文对Gln peptides的制备方法、结构解析等相关研究结果进行综述,旨在为具有特征性结构的生物活性肽开发提供新思路;同时总结Gln peptides在保护肠道活性、缓解抑郁、抗氧化、抗疲劳及免疫调节方面的生物活性,旨在为促进人类营养健康和相关疾病干预提供新视角;此外,本文还对Gln peptides在食品领域的应用前景进行展望,旨在提升Gln peptides的食品营养价值并为健康效益提供理论参考。

关键词: 谷氨酰胺肽;制备方法;结构解析;生物活性;营养健康

Abstract: Glutamine peptides (Gln peptides) refer to bioactive peptides containing glutamine (Gln) monomers at the non-N-terminus. Gln peptides are mainly derived from wheat proteins, corn proteins and other plant proteins, with strong stability, easy digestion and a variety of biological activities. In recent years, the development and application of Gln peptides have attracted the attention of researchers at home and abroad. In this article, the preparation methods and structure analysis of Gln peptides are reviewed, with the aim of providing new ideas for the development of bioactive peptides with characteristic structures. In addition, this article summarizes the biological activities of Gln peptides such as protecting intestinal activity, alleviating depression, antioxidant, anti-fatigue and immunomodulatory effects in order to provide a new perspective for promoting human nutritional health and related disease intervention. Finally, this article concludes with an outlook on the future application prospects of Gln peptides in the food field, aiming to provide a theoretical reference for improving the nutritional value and enhancing the health benefits of Gln peptides.

Key words: glutamine peptides; preparation methods; structural elucidation; biological activity; nutritional health

中图分类号: