食品科学 ›› 2025, Vol. 46 ›› Issue (18): 384-338.doi: 10.7506/spkx1002-6630-20250408-069

• 专题论述 • 上一篇    下一篇

基于斑马鱼模型的食品功能可视化评价研究进展

王朵朵,李滨,郑特,杨静,王其菲,周家妁,徐慧娟,王玉婷,张云   

  1. (齐鲁工业大学(山东省科学院),山东省科学院生物研究所,山东省人类疾病斑马鱼模型与药物筛选工程技术研究中心,山东?济南 250103)
  • 出版日期:2025-09-25 发布日期:2025-08-19
  • 基金资助:
    “十四五”国家重点研发计划重点专项(2022YFC2804600);泰山学者工程资助项目(tsqn202211204); 济南市“新高校20条”资助项目(2021GXRC047)

Research Progress on Visual Evaluation of Food Functions Using Zebrafish as an Animal Model

WANG Duoduo, LI Bin, ZHENG Te, YANG Jing, WANG Qifei, ZHOU Jiashuo, XU Huijuan, WANG Yuting, ZHANG Yun   

  1. (Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China)
  • Online:2025-09-25 Published:2025-08-19

摘要: 近年来,随着人们对食品营养与功能的关注度不断提高,对食品及其营养成分功能的可视化评价技术需求日益迫切。斑马鱼模型作为一种新兴的实验动物模型,凭借其体积小、繁殖速度快、与人类基因同源性高、易于饲养和观察等诸多优势,在食品及其营养成分功能的可视化评价中得到了广泛应用。本文系统论述了斑马鱼模型在心血管保护、肝脏保护、神经保护、骨骼发育调节、免疫增强、抗炎、抗氧化、糖代谢调控、皮肤美容等多个领域的功能评价技术及实际应用情况。同时,介绍了基因编辑、高通量筛选与大数据分析等多学科交叉融合的前沿技术在利用斑马鱼模型进行食品功能评价中的应用,并对斑马鱼模型在食品及其营养成分功能评价领域的未来发展前景进行了展望。

关键词: 斑马鱼;食品;营养成分;可视化;功能评价

Abstract: In recent years, with the increasing attention paid to the nutrition and functions of food, the demand for visual evaluation technologies for food and its nutritional components has become increasingly urgent. Zebrafish, with its advantages such as small size, fast reproduction rate, high homology with human genes, easy breeding and observation, has been widely applied as an animal model for the visual evaluation of food and its nutritional components. This review systematically discusses the application of zebrafish in the visual functional evaluation of food in multiple fields including cardiovascular protection, liver protection, neuroprotection, regulation of bone development, immune enhancement, anti-inflammatory effect, antioxidant effect, regulation of glucose metabolism, and skin beautification. Meanwhile, it outlines the application of cutting-edge multidisciplinary technologies such as gene editing, high-throughput screening and big data analysis in the functional evaluation of foods using zebrafish, and discusses future prospects for zebrafish in the functional evaluation of food and its nutritional components.

Key words: zebrafish; food; nutritional components; visualization; functional evaluation

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