神经酸生物合成、纯化及营养应用研究进展

doi:10.7506/spkx1002-6630-20250927-222

食品科学 ›› 2026, Vol. 47 ›› Issue (5): 13-25.doi: 10.7506/spkx1002-6630-20250927-222

• 功能性脂质生物制造专栏 • 上一篇

神经酸生物合成、纯化及营养应用研究进展

高云旗，张逸，周梦舟，陈洋，胡珊，孙周亮，郭宏涛，平磊，郑明明

（1.湖北工业大学生命科学与健康工程学院，湖北武汉 430062；2.中国农业科学院油料作物研究所，油料脂质化学与营养湖北省重点实验室，湖北武汉 430062；3.深圳市丽美康生物科技有限公司，广东深圳 518107；4.安琪酶制剂（宜昌）有限公司，湖北宜昌 443000）

发布日期:2026-04-13
基金资助:
国家重点研发计划政府间国际科技创新合作重点专项（2025YFE0111500）；湖北省重点研发计划项目（2024BBB040）；中央级科研院所基本科研业务费专项（1610172024002）

Research Progress in the Biosynthesis, Purification and Nutritional Application of Nervonic Acid

GAO Yunqi, ZHANG Yi, ZHOU Mengzhou, CHEN Yang, HU Shan, SUN Zhouliang, GUO Hongtao, PING Lei, ZHENG Mingming

(1. School of Life and Health Sciences, Hubei University of Technology, Wuhan 430062, China; 2. Hubei Key Laboratory of Lipid Chemistry and Nutrition of Oil Crops, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430062, China; 3. Shenzhen Limeikang Biotechnology Co. Ltd., Shenzhen 518107, China; 4. Angie Enzyme (Yichang) Co. Ltd., Yichang 443000, China)

Published:2026-04-13

摘要/Abstract

摘要： 神经酸是一种超长链单不饱和脂肪酸，具有促进神经再生、调节脂质代谢等生理功效，其在婴幼儿配方奶粉、保健品、医药等领域具有广泛应用潜力。本文概述动物、植物、微生物等不同来源的天然神经酸分布特点，重点探讨基于解脂耶氏酵母、圆红冬孢酵母等产油微生物生物合成神经酸的研究进展，阐明神经酸生物制造的工业化前景。在此基础上，论述神经酸的富集精制、功效评价及产品开发的发展趋势和未来展望。本综述旨在为神经酸的生物制造提供理论基础，为其工业化生产和高值化应用提供科学参考。

关键词: 神经酸；生物合成；富集精制；功能性脂质；产品开发

Abstract: Nervonic acid is a very long-chain monounsaturated fatty acid with physiological effects including promoting nerve regeneration and regulating lipid metabolism. It has wide application potential in fields such as infant formula, health foods, and medicine. This review summarizes the distribution characteristics of natural nervonic acid from different sources such as animals, plants and microorganisms, focusing on recent progress in the biosynthesis of nervonic acid using oleaginous microorganisms such as Yarrowia lipolytica and Rhodosporidium toruloides. We shed light on the industrial prospects of its biomanufacturing. On this basis, we address the development trends and future prospects of nervonic acid enrichment and purification, efficacy evaluation and product development. This review aims to provide a theoretical basis for the biological manufacturing of nervonic acid and offer a scientific reference for its industrial production and high-value applications.

Key words: nervonic acid; biosynthesis; enrichment and purification; functional lipids; product development

中图分类号:

Q548

高云旗，张逸，周梦舟，陈洋，胡珊，孙周亮，郭宏涛，平磊，郑明明. 神经酸生物合成、纯化及营养应用研究进展[J]. 食品科学, 2026, 47(5): 13-25.

GAO Yunqi, ZHANG Yi, ZHOU Mengzhou, CHEN Yang, HU Shan, SUN Zhouliang, GUO Hongtao, PING Lei, ZHENG Mingming. Research Progress in the Biosynthesis, Purification and Nutritional Application of Nervonic Acid[J]. FOOD SCIENCE, 2026, 47(5): 13-25.

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神经酸生物合成、纯化及营养应用研究进展

Research Progress in the Biosynthesis, Purification and Nutritional Application of Nervonic Acid

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