苜蓿提取物减肥作用的动物实验研究

doi:10.7506/spkx1002-6300-201003054

食品科学 ›› 2010, Vol. 31 ›› Issue (3): 235-238.doi: 10.7506/spkx1002-6300-201003054

苜蓿提取物减肥作用的动物实验研究

李兰芳，李国风，郝娜，张勤增，解丽君，尚涛，李丽萍，王薇

河北省疾病预防控制中心

收稿日期:2009-05-11 出版日期:2010-02-01 发布日期:2010-12-29
通讯作者: 李兰芳 E-mail:yaoyanllf@163.com
基金资助:
河北省科学技术研究与发展计划项目(04276101D-51)

Effect of Extract from Medicago sativa L. on Weight Loss in Rats with Nutritional Obesity

LI Lan-fang，LI Guo-feng，HAO Na，ZHANG Qin-zeng，XIE Li-jun，SHANG Tao，LI Li-ping，WANG Wei

Hebei Provincial Center of Disease Prevention and Control, Shijiazhuang 050021, China

Received:2009-05-11 Online:2010-02-01 Published:2010-12-29
Contact: LI Lan-fang E-mail:yaoyanllf@163.com

摘要/Abstract

摘要：

目的：研究苜蓿提取物对营养肥胖型大鼠的减肥作用。方法：将刚断乳的 60 只SD 大鼠随机分为6 组：空白对照组、肥胖模型组、阳性对照组(曲美)、苜蓿提取物1.80、0.90、0.45g/kg bw 3 个剂量组，除空白对照组给正常饲料外，其余各组均饲喂营养饲料，每天灌胃给受试物1 次，连续70d，每周称量大鼠体质量2 次。实验结束，分别测定大鼠体质量，脂/ 体质量比，Lee’s 指数，血清及肝脏TC 和TG 的含量及脂肪组织结构变化，同时检测血红蛋白、血清白蛋白、血糖含量。结果：与肥胖模型组比较，苜蓿提取物能显著降低大鼠体质量、脂肪质量、脂/ 体比；降低Lee’s 指数；使血清和肝脏TC 含量下降；使生殖器周围脂肪细胞颗粒变小；不影响血红蛋白、血清白蛋白、血糖含量。结论：苜蓿提取物对营养型肥胖大鼠有明显的减肥作用，副作用小，值得进一步深入开发其减肥用途。

关键词: 苜蓿提取物, 减肥, 营养肥胖大鼠, 降脂

Abstract:

Objective: To investigate the effect of extract from Medicago sativa L. (MSE) on weight loss in rats with nutritional obesity. Methods: Sixty weaning male rats were randomly divided into 6 groups, including control group, obesity model group, positive control group administered sibutramine and MSE treatment groups at the doses of 1.80, 0.90 g/kg bw and 0.45 g/kg bw. The rats in control group were fed normal diet and those in other groups were fed nutritional diet and administered experimental drugs once a day for 70 consecutive days. All rats were weighed twice a week. Body weight, body fat percentage, Lee’s index, contents of TC and TG in serum and liver, albumin, blood sugar and hemoglobin were determined at the end of experiments. Results: MSE exhibited a significant reduction effect on body weight, fat tissue around testicle and kidney, body fat percentage and Lee’s index. Meanwhile, MSE also resulted in a significant decrease in total cholesterol and an inhibition effect on growth of fat cells around the genitals in obese rats. However, no obvious change of blood sugar, albumin, TG and hemoglobin was observed in obese rats treated with MSE. Conclusion: MSE has a function of weight loss in obese rats without side effects, which is worthy of in-depth development.

Key words: extract from Medicago sativa L., weight loss, rats with nutritional obesity, hypolipidemic effect

中图分类号:

S551.7

李兰芳，李国风，郝娜，张勤增，解丽君，尚涛，李丽萍，王薇. 苜蓿提取物减肥作用的动物实验研究[J]. 食品科学, 2010, 31(3): 235-238.

LI Lan-fang，LI Guo-feng，HAO Na，ZHANG Qin-zeng，XIE Li-jun，SHANG Tao，LI Li-ping，WANG Wei. Effect of Extract from Medicago sativa L. on Weight Loss in Rats with Nutritional Obesity[J]. FOOD SCIENCE, 2010, 31(3): 235-238.

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苜蓿提取物减肥作用的动物实验研究

Effect of Extract from Medicago sativa L. on Weight Loss in Rats with Nutritional Obesity

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