食品科学 ›› 2010, Vol. 31 ›› Issue (3): 230-234.doi: 10.7506/spkx1002-6300-201003053

• 营养卫生 • 上一篇    下一篇

蓝靛果花色苷对高脂膳食诱导肥胖大鼠脂代谢和抗氧化能力影响

焦岩1,王振宇1.2   

  1. 1.东北林业大学林学院 2.哈尔滨工业大学食品科学与工程学院
  • 收稿日期:2009-04-01 出版日期:2010-02-01 发布日期:2010-12-29
  • 通讯作者: 王振宇 E-mail:jiaoyan_3000@126.com
  • 基金资助:

    哈尔滨市重大科技攻关计划项目(2008AA6AN087);国家林业局林业科技成果推广项目

Effect of Lonicera caerulea Anthocyanin on Lipid Metabolism and Antioxidant Function in High Fat Diet-induced Obese Rats

JIAO Yan1,WANG Zhen-Yu1,2,*   

  1. 1. School of Forestry, Northeast Forestry University, Harbin 150040, China ;
    2. College of Food Science and Engineering,Harbin Institute of Technology, Harbin 150001, China
  • Received:2009-04-01 Online:2010-02-01 Published:2010-12-29
  • Contact: WANG Zhen-Yu E-mail:jiaoyan_3000@126.com

摘要:

目的:研究蓝靛果果渣花色苷(Lonicera caerulea residue anthocyanin,LCRA)对高脂膳食诱导肥胖大鼠脂类代谢和抗氧化能力的影响。方法:将大鼠随机分为基础对照,肥胖模型对照和低、中、高剂量花色苷共5 组,即4.0、40.0、120mg/kg bw·d 的花色苷灌胃,基础对照组和肥胖模型对照组分别灌胃生理盐水(1.2g/kg bw·d);连续28d 后,分别测定大鼠体质量、脂肪、肝脏质量,血清总胆固醇(TC)、总甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)含量以及肝脏脂肪酶(LPS)、肝脂酶(HL)、脂蛋白脂肪酶(LPL)、超氧化歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)的活性和脂质过氧化物(MDA)含量。结果:与肥胖模型对照组相比,LCRA能显著降低肥胖模型大鼠血脂水平,使肝脏LPS、HL、LPL、SOD 和GSH-Px 活性明显增强,MDA 的生成量显著减少。结论:LCRA 对高脂膳食诱导肥胖大鼠脂代谢有明显调节作用,可有效减少肝脏过氧化损伤,预防动脉硬化的发生。

关键词: 蓝靛果果渣, 花色苷, 脂代谢, 抗氧化

Abstract:

Objective: To study the effect of anthocyanin extracted from Lonicera caerulea residue (LCRA) on lipid metabolism and antioxidant function in high fat diet-induced obese rats. Methods: Rats were divided into 5 groups, inluding normal control group, obesity model group and LCRA low-, medium- and high-dose groups treated with LCRA at doses of 4.0, 40.0 mg/kg bw·d and 120 mg/kg bw·d. Normal control and obesity model groups were fed normal saline at the dose of 1.2 g/kg bw·d for 28 consecutive days. After administration, body and liver weight, body fat percentage, total triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), activities of HL, LPL, LPS, SOD and GSH-Px, and MDA content in liver were measured. Results: Compared with obesity model group, LCRA treated groups exhibited a significant reduction in serum lipid level and MDA content in liver and a significant increase in the activities of HL, LPL, LPS, SOD and GSH-Px in liver. Conclusion: LCRA can improve lipid metabolism in high fat diet-induced obese rats, which reveals strong functions for reducing peroxidative liver injury and preventing arteriosclerosis.

Key words: Lonicera caerulea residue, anthocyanin, lipid metabolism, antioxidant function

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