食品科学 ›› 2007, Vol. 28 ›› Issue (11): 558-560.

• 营养卫生 • 上一篇    下一篇

猪毛菜不同提取物对高血压模型大鼠血压和心率的影响

 刘建学, 孟祥平, 张晓慧   

  1. 河南科技大学食品与生物工程学院; 河南科技大学食品与生物工程学院 河南洛阳471003; 河南洛阳471003;
  • 出版日期:2007-11-15 发布日期:2011-11-22

Effects of Blood Pressure and Heart Rate of Hypertension Rats with Different Extracts of Salsola

 LIU  Jian-Xue, MENG  Xiang-Ping, ZHANG  Xiao-Hui   

  1. Department of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471003, China
  • Online:2007-11-15 Published:2011-11-22

摘要: 目的:观察猪毛菜乙醇提取物和猪毛菜生物总碱对药物诱导的高血压大鼠血压和心率的影响。方法:采用腹腔注射左旋硝基精氨酸制造大鼠高血压模型,在左旋硝基精氨酸高血压的状态下,分别给大鼠猪毛菜乙醇提取物和猪毛菜生物总碱,记录给药2周后的收缩压、舒张压和心率变化。结论:两种提取物对左旋硝基精氨酸引起的高血压模型大鼠均有降压作用,给药前后比较差异有高度显著性(p<0.01),猪毛菜生物总碱的降压效果强于乙醇提取物,确定生物总碱为其一种降压活性成分。

关键词: 左旋硝基精氨酸, 高血压, 猪毛菜, 乙醇提取物, 生物总碱, 降压

Abstract: Objective: To observe effects of different extracts from Salsola on blood pressure in hypertension rats. Methods: Sprague-Dawley rats were injected L-NNA to achieve murine hypertension models, then were given different extracts of Salsola and the systolic pressure(SP), diastolic pressure(DP) and heart rate (HR) were recorded. Conclusion: Two kinds of extracts of Salsola all have effective hypotension results in rats with L-NNA caused hypertension, There was statistically significant difference in comparisons between before and after being given medicine (p<0.01), and the alkaloild effects of depressing blood pressure are better than alcoholic extracts. Alkaloid is a kind of active ingredient of depressing blood.

Key words: L-NNA, hypertension, Salsola, alcoholic extracts, alkaloid, decompression