食品科学 ›› 2006, Vol. 27 ›› Issue (8): 248-250.

• 营养卫生 • 上一篇    下一篇

甘薯叶柄藤类黄酮的抗肿瘤作用研究

 罗丽萍,  高荫榆,  洪雪娥,  夏冬华,  陈才水   

  1. 南昌大学食品科学教育部重点实验室
  • 出版日期:2006-08-15 发布日期:2011-10-14

Study on Anti-tumor Effects of Flavonoids Extracted from Sweet Potato Leaf,Stalk and Stem

 LUO  Li-Ping,   Gao-Yin-Yu,   Hong-Xue-E,   Xia-Dong-Hua,   Chen-Cai-Shui   

  1. Key Laboratory of Food Science,Ministry of Education,Nanchang University,Nanchang 330047,China
  • Online:2006-08-15 Published:2011-10-14

摘要: 研究薯蔓黄酮(FSPV)对瘤株和动物的抗肿瘤作用。采用MTT法研究FSPV对4种瘤株生长的抑制作用;以动物移植性肿瘤肉瘤S180为模型,以环磷酰胺为阳性对照,以生理盐水为阴性对照,观察FSPV对动物的抗肿瘤作用。结果表明:FSPV能显著抑制4种瘤株的生长,并呈一定的剂量浓度关系;尤其对HL-60瘤株效果最佳。FSPV对S180荷瘤小鼠有较强的抑瘤作用(p<0.05),并以中剂量(400mg/kgbw)的抑瘤率最高;结论:FSPV对4种瘤株和移植性S180肉瘤小鼠具有抗肿瘤作用。

关键词: 甘薯叶柄藤, 黄酮, 抗肿瘤作用, MTT法

Abstract: The antitumor effects of FSPV were studied in this paper.By using MTT assay and dye exclusion method,the inhibitory effects on 4 tumor cell lines in vitro of FSPV were studied.Cyclophosphamide was the positive control and saline the negative control.S180-bearing mice were used as animal model.The changes of tumor weight in vitro were investigated when FSPV were used.Results:The growth of 4 tumor cells is inhibited by FSPV significantly in dose-dependent manner.Especially the inhibitory effect on the HL-60 is specific up to 70.95%.The antitumor effect of FSPV on the S180 bearing mice is significant.The inhibitory rate is highest when the dose is 400mg/kg bw.Conclusion:FSPV have the antitumor effects on the 4 tumor cell lines and S180-bearing mice.

Key words: sweet potato leaf,stalk and stem, flavonoids, anti-tumor effect, MTT assay