食品科学 ›› 2019, Vol. 40 ›› Issue (9): 309-315.doi: 10.7506/spkx1002-6630-20180129-404

• 专题论述 • 上一篇    下一篇

膳食营养素与炎症性肠病关系研究进展

杨小冰1,金明玉1,吴小禾2,尹 辉3,吴小勇4,*   

  1. 1.广东药科大学公共卫生学院,广东 广州 510310;2.中山火炬职业技术学院生物医药系,广东 中山 528436;3.广东药科大学生命科学与生物制药学院,广东 广州 510006;4.广东药科大学食品科学学院,广东 中山 528453
  • 出版日期:2019-05-15 发布日期:2019-05-28
  • 基金资助:
    国家自然科学基金面上项目(81770527)

Progress in Understanding the Relationship between Dietary Nutrients and Inflammatory Bowel Disease

YANG Xiaobing1, JIN Mingyu1, WU Xiaohe2, YIN Hui3, WU Xiaoyong4,*   

  1. 1. School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China; 2. Department of Biomedicine, Zhongshan Torch Polytechnic, Zhongshan 528436, China; 3. School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China; 4. School of Food Science, Guangdong Pharmaceutical University, Zhongshan 528453, China
  • Online:2019-05-15 Published:2019-05-28

摘要: 炎症性肠病(inflammation bowel disease,IBD)是一组以肠道炎症性细胞浸润、肠黏膜受损为主要表现的肠道慢性炎症病变,包括溃疡性结肠炎和克罗恩氏病。流行病学调查结果显示,高脂摄入增加IBD的发病风险,IBD的发病率与居民动物蛋白摄入量的增加有一定的关联性,膳食纤维摄入量与IBD发病率呈负相关。IBD的发病机制复杂,主要包括遗传因素和环境因素,其中饮食是重要的环境因素之一;目前膳食营养干预是防治IBD的有效策略。本文综述了近年来膳食脂肪、蛋白质、碳水化合物三大营养素对IBD发病机制影响方面的研究,并从膳食营养素的角度综合分析了IBD的饮食干预治疗策略。

关键词: 膳食营养素, 炎症性肠病, 发病机制, 饮食干预

Abstract: Inflammatory bowel disease (IBD) is a group of chronic inflammatory intestinal disorders characterized by intestinal inflammatory cell infiltration and intestinal mucosal damage, including ulcerative colitis and Crohn’s disease. Epidemiological findings indicated that high fat intake increased the risk of developing IBD, the incidence of IBD was associated with increased intake of animal proteins, and dietary fiber intake was negatively correlated with the incidence of IBD. The pathogenesis of IBD is complex, including genetic factors and environmental factors, of which diet is one of the most important environmental factors. Currently, dietary nutrition intervention is an effective strategy for the prevention and control of IBD. In this review we summarize recent studies on the effects of dietary fat, proteins and carbohydrates on the pathogenesis of IBD, and analyze dietary intervention strategies against IBD from the perspective of dietary nutrients.

Key words: dietary nutrients, inflammatory bowel disease, pathogenesis, dietary intervention

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