食品科学 ›› 2021, Vol. 42 ›› Issue (9): 233-240.doi: 10.7506/spkx1002-6630-20200404-050

• 专题论述 • 上一篇    下一篇

植物提取物对晚期糖基化终产物抑制机理的研究进展

韩喻,扈莹莹,贺菁蕾,王辉,陈倩,秦立刚   

  1. (1.东北农业大学食品学院,黑龙江 哈尔滨 150030;2.东北农业大学动物科学技术学院,黑龙江 哈尔滨 150030)
  • 出版日期:2021-05-15 发布日期:2021-06-02
  • 基金资助:
    国家自然科学基金青年科学基金项目(31702160);哈尔滨市科技创新人才项目(2017RAQXJ007); 黑龙江省高校创新人才项目(UNPYSCT-2018144)

Progress in Understanding the Inhibitory Mechanism of Plant Extracts on Advanced Glycation End Products

HAN Yu, HU Yingying, HE Jinglei, WANG Hui, CHEN Qian, QIN Ligang   

  1. (1. School of Food Science, Northeast Agricultural University, Harbin 150030, China;2. College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China)
  • Online:2021-05-15 Published:2021-06-02

摘要: 晚期糖基化终产物(advanced glycation end products,AGEs)是由还原糖中的羰基与蛋白质、脂类和核酸中的游离氨基反应所形成的一类物质的总称,目前已证实该类物质具有一定的致病性,会导致神经退行性疾病、炎症反应、心脑血管疾病、糖尿病和癌症等疾病。本文旨在概述AGEs的来源、形成途径以及对人体的致病性,并重点介绍了植物提取物对于AGEs抑制机理的研究现状,为控制食品加工过程中产生的AGEs提供理论依据。

关键词: 晚期糖基化终产物;形成途径;植物提取物;抑制机理

Abstract: Advanced glycation end products (AGEs) encompass a class of substances formed by the reaction of free amino groups in proteins, lipids or nucleic acid with carbonyl groups in reducing sugars. It has been confirmed that these substances are pathogenic and can cause neurodegenerative diseases, inflammatory reactions, cardiovascular and cerebrovascular diseases, diabetes, cancer and other diseases. The purpose of this article is to summarize the origin, formation mechanism and pathogenicity of AGEs, with focus on the current status in research on the inhibitory mechanism of plant extracts on AGEs, which can provide a theoretical basis for controlling the production of AGEs during food processing.

Key words: advanced glycation end products; formation pathways; plant extracts; inhibition mechanism

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