关键词: 晚期糖基化终末产物；形成；致病机理；代谢；抑制

Abstract: Advanced glycation end products (AGEs) are a series of stable compounds generated by the nonenzymatic reaction of reducing sugars with proteins, lipids or nucleic acids. It has been found that the excessive accumulation of AGEs in the body can easily cause various chronic diseases such as diabetes, atherosclerosis, Alzheimer’s diseases and cardiovascular diseases. Finding methods to suppress the formation of AGEs is of great significance for ensuring human health. This article summarizes the types, structures, formation process, pathogenesis, and in vivo metabolic pathways of AGEs, with a focus on the methods and mechanisms for the inhibition of AGEs. This review will provide a theoretical basis for controlling the formation of AGEs.

Key words: advanced glycation end products; formation; pathogenesis; metabolism; inhibition