食品科学 ›› 2023, Vol. 44 ›› Issue (17): 196-214.doi: 10.7506/spkx1002-6630-20220830-351

• 专题论述 • 上一篇    下一篇

解脂耶氏酵母产赤藓糖醇研究进展

李砷,牟志勇,严鑫,艾连中,夏永军,宋馨,田延军,张辉,倪斌,杨昳津   

  1. (1.上海理工大学健康科学与工程学院,上海 200093;2.上海金枫酒业股份有限公司,上海 200093)
  • 出版日期:2023-09-15 发布日期:2023-09-29
  • 基金资助:
    国家自然科学基金青年科学基金项目(32001674);上海食品微生物工程技术研究中心项目(19DZ2281100); 上海市金山区产学研成果转化项目(2021-CXY-06)

Research Progress on Erythritol Production by Yarrowia lipolytica

LI Shen, MU Zhiyong, YAN Xin, AI Lianzhong, XIA Yongjun, SONG Xin, TIAN Yanjun, ZHANG Hui, NI Bin, YANG Yijin   

  1. (1. School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; 2. Shanghai Jinfeng Wine Co., Ltd., Shanghai 200093, China)
  • Online:2023-09-15 Published:2023-09-29

摘要: 赤藓糖醇是一种天然甜味剂,因具有热量低、稳定性好、食用安全性高等优点,被广泛应用于食品、医药及化工等行业。解脂耶氏酵母作为赤藓糖醇的高效发酵菌株,被广泛用于赤藓糖醇的工业生产中。但目前解脂耶氏酵母生产赤藓糖醇的相关研究主要集中于发酵过程控制与代谢途径调控等方面,还存在产量与技术上的瓶颈。基于此,本文从发酵基质利用、发酵过程控制及基因工程改造代谢途径3 个方面对解脂耶氏酵母生产赤藓糖醇的国内外研究进展进行综述,以期为日后突破解脂耶氏酵母产赤藓糖醇的产量与技术瓶颈提供参考依据。

关键词: 解脂耶氏酵母;赤藓糖醇;发酵;代谢途径

Abstract: Erythritol, a natural sweetener, is widely used in the food, medicinal and chemical industries because of its advantages of low calorie, good stability and high food safety. Yarrowia lipolytica is widely used as an efficient fermentation strain for erythritol production. However, the current research on erythritol production by Yarrowia lipolytica concentrates on control of the fermentation process and metabolic pathway regulation and has bottlenecks in the yield of erythritol and the fermentation process. On this basis, this article reviews recent progress in research on erythritol production by Yarrowia lipolytica from three aspects: fermentation substrate utilization, fermentation process control and metabolic pathway modification by genetic engineering. This review is expected to provide a reference for breaking the bottlenecks in erythritol production by Yarrowia lipolytica.

Key words: Yarrowia lipolytica; erythritol; fermentation; metabolic pathways

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