食品科学 ›› 2025, Vol. 46 ›› Issue (6): 371-380.doi: 10.7506/spkx1002-6630-20240910-084

• 专题论述 • 上一篇    下一篇

母乳中糖蛋白种类、功能、检测技术研究进展

刘晓佳,张晓梅,张明辉,李星,高子玥,赵军英,乔为仓,陈历俊   

  1. (1.东北农业大学食品学院,黑龙江 哈尔滨 150030;2.北京三元食品股份有限公司,国家母婴乳品健康工程技术研究中心,北京市乳品工程技术研究中心,母乳研究技术创新中心,北京 100163)
  • 出版日期:2025-03-25 发布日期:2025-03-10
  • 基金资助:
    北京市科技计划课题(Z221100006422012);北京市家畜创新团队项目(BAIC05); 首农食品集团自立科技项目(SNSPKJ(2022)03)

Research Progress in Types, Functions and Detection Techniques of Glycoproteins in Breast Milk

LIU Xiaojia, ZHANG Xiaomei, ZHANG Minghui, LI Xing, GAO Ziyue, ZHAO Junying, QIAO Weicang, CHEN Lijun   

  1. (1. College of Food Science, Northeast Agricultural University, Harbin 150030, China;2. National Engineering Research Center of Dairy Health for Maternal and Child, Beijing Engineering Research Center of Dairy, Technical Innovation Center of Human Milk Research, Beijing Sanyuan Food Co. Ltd., Beijing 100163, China)
  • Online:2025-03-25 Published:2025-03-10

摘要: 母乳中超过70%的蛋白质都会被糖基化,糖基化酶可以切割蛋白质连接聚糖的特定结构,但是人的消化系统并不分泌糖基化酶,所以糖基化蛋白比非糖基化蛋白更有可能在消化系统中完整存活并发挥功能。本文介绍母乳中糖蛋白的种类、组成及含量,分析母乳中糖蛋白生物学功能的作用机制,综述糖蛋白组学的研究进展,为进一步研究母乳中糖蛋白的生物学功能提供参考。

关键词: 母乳;糖蛋白;生物学功能;检测技术;蛋白质组学;糖基化位点

Abstract: More than 70% of proteins in breast milk are glycosylated, and glycosylation enzymes cleave specific structures that connect proteins to polysaccharides. However, the human digestive system does not secrete glycosylation enzymes. Therefore, glycosylated proteins are more likely to retain their activity and exert their functions in the digestive system compared with non-glycosylated proteins. This article introduces the types, composition and content of glycoproteins in breast milk, analyzes the mechanism underlying their biological functions, and reviews recent progress in glycoproteomics. We expect that this review will provide a reference for research on the biological functions of glycoproteins in breast milk.

Key words: breast milk; glycoprotein; biological function; detection techniques; proteomics; glycosylation site

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