食品科学 ›› 2025, Vol. 46 ›› Issue (19): 347-359.doi: 10.7506/spkx1002-6630-20241218-156

• 专题论述 • 上一篇    

类器官技术在营养评价中的应用

何牮,周献超,张晶晶,沈梦碧,孟梅,邱红玲,王慧   

  1. (上海交通大学公共卫生学院,上海 200025)
  • 发布日期:2025-09-16
  • 基金资助:
    “十四五”国家重点研发计划重点专项(2022YFD2101503)

Application of Organoid Technology in Nutritional Evaluation

HE Jian, ZHOU Xianchao, ZHANG Jingjing, SHEN Mengbi, MENG Mei, QIU Hongling, WANG Hui   

  1. (School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China)
  • Published:2025-09-16

摘要: 在营养评价中,类器官作为一种新兴技术,展现了较传统细胞和动物模型更具生理相关性的研究优势。类器官复杂的三维模型能重现人类器官的功能和结构,使其在营养吸收、代谢、膳食干预和营养失衡影响评估等方面具有独特应用。本综述重点介绍各种类器官模型(如肠道、肝脏、肾脏、大脑等类器官)在营养评估中的应用场景及方法。尽管面临成本高、标准化不足等挑战,随着技术的不断进步,类器官的应用范围正在不断扩展。本综述旨在总结类器官在营养评价中的当前研究进展和未来发展方向。

关键词: 类器官;营养;评价

Abstract: Organoids, as a cutting-edge technology in nutritional evaluation, demonstrate research advantages with greater physiological relevance over traditional cell and animal models. These complex 3D models replicate the structures and functions of human organs, having unique applications in assessing nutrient absorption, metabolism, dietary interventions, and the effects of nutritional imbalances. This review highlights the application scenarios and methodologies of various organoid models-such as intestinal, liver, kidney, and brain organoids-in nutritional assessment. Despite challenges like high costs and insufficient standardization, the application scope of organoids is rapidly expanding with ongoing technological advancements. This review summarizes the current research progress and future directions of organoids in nutritional evaluation.

Key words: organoids; nutrition; evaluation

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