Abstract:

In order to investigate the toxicity of transgenic carp with salmon growth hormone gene, mice were fed diet containing flesh of transgenic carp with salmon growth hormone gene or non-transgenic carp. The diets containing flesh of transgenic carp with different proportions of 10%, 5% and 2.5% were given to mice for 90 consecutive days. Acute oral toxicity experimental results revealed that mice fed transgenic carp were normal as the control group fed non-transgenic carp during the period of 90 days. The mice exhibited free movements and shining coats without any abnormal symptoms and abnormal secretions in their noses, eyes and mouths. Meanwhile, no obvious difference in toxic indices between experimental group and control group was observed. Moreover, no abnormal change in hematological and biochemical indices, routine urine test, viscera coefficients and histopathological examinations was observed in mice fed transgenic carp with salmon growth hormone gene. Therefore, salmon growth hormone gene has no toxicity and transgenic carps are safe to mice as edible foods.

Key words: transgenic carp with salmon growth hormone gene, edibility, safety, toxicity