Abstract:

In this study, the blood and organ coefficients of mice with long-term intake of Sudan I were investigated. Totally 40 male Kunming mice were randomly divided into 4 groups, which were designated as control group fed normal diet and three groups fed diets containing Sudan I at doses of 250, 500, 1000 mg/kg. Body weight (bw) determination and blood routine examination were conducted every 10 days. After 60 days, all mice were sacrificed and organ coefficients were calculated. Results indicated that slow body weight gain of the mice fed dietcontaining Sudan I was observed during the period of 60 days. The coefficients of liver/bw, spleen/bw and kidney/bw in the mice fed diet containing Sudan I were all obviously higher than those of the control mice. In addition, with increasing intake time of Sudan I, the number of red blood cells and the content of hemoglobin of mice exhibited a gradual decrease trend; In contrast, the number of white blood cells and clotting time exhibited an increase trend, especially for the mice in the group fed diet containing Sudan I at the dose of 1000 mg/kg. These investigations confirm that Sudan I can resulted in the damage of blood cells and organs.

Key words: Sudan I, Kunming mice, blood routine examination, organ coefficient