Abstract:

To investigate hypolipidemic and antioxidant effects of tartary buckwheat proteins (albumin, globulin, glutelin and their mixture) in vivo, healthy Kunming male mice were fed high-fat diet to create a hyperlipidemic animal model. Results showed that all the various tartary buckwheat proteins had hypolipidemic and antioxidant effects in mice and both effects were decreased in the following order: albumin ＞globulin ＞ glutelin. Either high- or low-dose albumin administration, or high-dose globulin administration resulted in a significant reduction of serum total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL-C) contents (P＜0.05) and a significant increase of high-density lipoprotein (HDL-C) content in hyperlipidemic mice (P＜0.05). This means a remarkable hyperlipidemic effect. Meanwhile, hyperlipidemic mice administered albumin at the low-dose level exhibited a significantly reduced content of molondialdehyde (MDA), a peroxidation product and significantly enhanced activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in both serum and liver (P ＜ 0.05) when compared with hyperlipidemic mice without any administration.

Key words: protein components of tartary buckwheat, hypocholesterolaemic effect, antioxidant effect