Improving Effects of Zhenggaofang-Guilinggao on Oxidative Stress Status

doi:10.7506/spkx1002-6630-200905055

FOOD SCIENCE ›› 2009, Vol. 30 ›› Issue (5): 239-243.doi: 10.7506/spkx1002-6630-200905055

Previous Articles Next Articles

Improving Effects of Zhenggaofang-Guilinggao on Oxidative Stress Status

YIN Xiao-ping1，LIN Guan-yu1， BAO Li2，YAO Xin-sheng1,2， KURIHARA Hiroshi1,*

(1.Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China；
2.College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China)

Received:2008-03-24 Revised:2008-05-23 Online:2009-03-01 Published:2010-12-29
Contact: KURIHARA Hiroshi1,* E-mail:hiroshi_kurihara@163.com

Abstract

Abstract:

Objective：To investigate the protective effects of Zhenggaofang-Guilinggao (GLG) on liver injury of mice induced by restraint stress. Methods：The liver injury model of mice was established under restraint stress for 18 h. Hepatic function was evaluated through assaying alanine aminotransferase (ALT) activity in plasmabu by Reitman-Frankel method, malondialdehyde (MDA ) content by TBARS method. NO content by Griess chemical method, oxygen radical absorbance capacity (ORAC) using enzyme-mark instrument, glutathione (GSH) level by HPLC method, and hepatic glutathione peroxidase (GPX) and glutathione S-transferase (GST) activities by colorimetric method. Results: Compared with the control group of restraint stress, GLG can significantly decrease the ALT activity and the contents of MDA and NO, and increase the levels of ORAC and GSH, the acticities of GPX and GST in liver. Conclusion: GLG has protective effects on liver injury in mice loaded with restraint stress, and the effect may be related to its ability of releasing the level of oxidative stress in mice.

Key words: Zhenggaofang-Guilinggao (GLG), restraint stress, liver injury, oxidative stress status

CLC Number:

YIN Xiao-ping1，LIN Guan-yu1， BAO Li2，YAO Xin-sheng1,2， KURIHARA Hiroshi1,*. Improving Effects of Zhenggaofang-Guilinggao on Oxidative Stress Status[J]. FOOD SCIENCE, 2009, 30(5): 239-243.

[1]	YANG Zhongmin, SHEN Yihong, HUANG Xianzhi, WANG Zuwen, DING Xiaowen. Improvement Effect of Mulberry Leaf Alkaloids on Abnormal Glucose and Lipid Metabolism and Liver Injury Induced by Oxidative Stress in Mice [J]. FOOD SCIENCE, 2021, 42(7): 156-161.
[2]	LI Fangfang, ZHANG Ruimeng, CONG He, SHEN Minghua. Protective Effects of Fibrinolytic Enzyme from Lyophyllum ulmarium on Alcohol-Induced Liver Injury in Rats [J]. FOOD SCIENCE, 2021, 42(17): 121-126.
[3]	JIANG Yang, ZHANG Cuiying, LI Yu, XIAO Dongguang. Effect of Flavor Substances in Alcoholic Beverages on Ethanol Metabolism in Human Body: A Review [J]. FOOD SCIENCE, 2021, 42(15): 242-250.
[4]	LIU Chen, FENG Xinhuan, DOU Zhihua, AN Shujing, LIU Mengjiao, HOU Zhimei, YANG Jie. Protective Effect of Xinjiang Bactrian Camel Milk on the Liver of Streptozotocin-Induced Diabetic Mice [J]. FOOD SCIENCE, 2020, 41(9): 74-80.
[5]	YU Lanlan, LIU Wei, ZHOU Yalin, LI Yong, QIN Yong, LI Ruijun, XU Yajun. Effects of Wheat Oligopeptides on Antioxidant Function of Mice with Acute Alcoholism [J]. FOOD SCIENCE, 2020, 41(7): 159-163.
[6]	LIU Shuting, WANG Ying, WANG Zhihui, WANG Di, ZHANG Yanli, ZUO Zhaohang, WANG Haoyu, DENG Wei. Repairing Effect of Resistant Starch from Purple Speckled Kidney Beans (Phaseolus vulgaris) on Liver and Intestinal Barrier Injury in Rats with Hyperlipidemia [J]. FOOD SCIENCE, 2020, 41(21): 106-112.
[7]	MA Chaoyang, ZHU Lijuan, LUO Chenxi, ZHU Zihan, KONG Li, LIN Xing, GAO Xinyu, MA Yurong, OU Zhaoping, YI Jin’e. Protective Effect of Betulinic Acid on Cyclophosphamide-Induced Liver Injury in Mice [J]. FOOD SCIENCE, 2020, 41(21): 147-153.
[8]	HUANG Ying, TAN Shuming, CHEN Ping, CHEN Xiaomin, SONG Zhangjun. Protective Effect of Polyphenols Extracted from Honey against Acute Alcoholic Liver Injury in Rats [J]. FOOD SCIENCE, 2020, 41(21): 154-159.
[9]	CUI Jingai, WANG Siji, LIU Chang, YU Ting, CHEN Xiaoping. Protective Effect and Mechanism of Inonotus obliquus Polysaccharide on Blood Lipids and Liver in Hyperlipidemia Rats Induced by High-Fat Diet [J]. FOOD SCIENCE, 2020, 41(19): 185-190.
[10]	QU Hang, GAO Xin, YI Juanjuan, WANG Zhenyu. Review on the Protective Effects of Food-Derived Natural Compounds on Alcohol-Induced Liver Injury [J]. FOOD SCIENCE, 2020, 41(17): 283-290.
[11]	JIANG Guoyong, LEI Aitong, YANG Ying, YU Qiang, XIE Jianhua, CHEN Yi. Protective Effect of Ganoderma atrum Polysaccharides against Acrylamide-Induced Liver Injury in Rats [J]. FOOD SCIENCE, 2020, 41(1): 121-126.
[12]	HAN Yuwei, LIU Yangyang, CHEN Wei. Synergistic Protective Effects of Cordyceps militaris Polysaccharide Supplemented Yogurt on Alcoholic Liver Injury in Kunming Mice [J]. FOOD SCIENCE, 2020, 41(1): 209-214.
[13]	ZHUO Yiyun, Lü Jing, LIU Ying, WANG Zilong, LIU Man, LIANG Hui. Nattokinase Alleviates Alcoholic Liver Injury and Modulates Immune Function in Rats [J]. FOOD SCIENCE, 2019, 40(7): 156-162.
[14]	QU Huiming, WANG Ying, ZHAO Bo, LIU Jianlong, LIU Kechun, SHEN Hong, CHU Jie. Protective Effect of β-Carotene on Liver Oxidative Damage Induced by Hydrogen Peroxide in Zebrafish [J]. FOOD SCIENCE, 2019, 40(5): 162-166.
[15]	ZHANG Yang, ZHU Caiping, LIN Yangnan, CAO Yulin, ZHANG Yifan, FANG Hao. Hepatoprotective Effect of Pleurotus ostreatus Polysaccharides on Carbon Tetrachloride-Induced Liver Injury in Male Kunming Mice [J]. FOOD SCIENCE, 2019, 40(23): 157-162.

Improving Effects of Zhenggaofang-Guilinggao on Oxidative Stress Status

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments