Abstract:

Polyfruitnol derived from blueberry, grapeseed, redwine and green tea was fortified with various vitamins and flavoring agents. The antiaging function of polyfruitnol to rat was investigated. 32 aging rats (18 months age) were randomly divided into 4 groups: 2 polyfruitnol-treated groups (50 and 100 mg/kg bw), VE group (35 mg/kg bw) and control group. All rats were administered with drugs or normal saline by gavage once a day for 16 days. After the administration, biochemical assay was conducted by measuring the activities of superoxide dismutase (SOD) in plasma and glutathione peroxidase (GSH-Px) in serum, and the contents of malodndaldegyde (MDA) in plasma, total cholesterol (TC) and triglyceride (TG) in serum and lipofuscin (LF) in heart. Results indicated that this polyfruitinol could significantly improve the activities of SOD and GSH-Px (p＜0.01) and is able to decrease the contents of the MDA and LF (p＜0.05), indicating that the polyfruitinol has certain antiaging function. The mechanisms may be associated with increasing the activities of antioxidation enzymes and preventing lipid peroxidation in tissues．

Key words: polyfruitinol, anti-aging effects, SOD, MDA, GSH-Px, LF