FOOD SCIENCE ›› 2009, Vol. 30 ›› Issue (17): 285-288.doi: 10.7506/spkx1002-6630-200917066

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Hypolipidemic Activity of Water Soluble Polysaccharide PMEP-1 from Morchella esculenta (L.) Pers

MING Jian1,2，ZENG Kai-fang1,2，ZHAO Guo-hua1,2，WU Su-rui3，GUI Ming-ying3，CHEN Zong-dao1,2,*   

  1. 1. College of Food Science, Southwest University, Chongqing 400715, China ；
    2. Chongqing Special Food Programme and Technology Research Center, Chongqing 400715, China；
    3. Kunming Research Institute of Edible Mushroom, Kuming 650223, China
  • Received:2009-03-24 Revised:2009-06-17 Online:2009-09-01 Published:2014-04-14
  • Contact: CHEN Zong-dao1,2,* E-mail:chenzd@swu.edu.cn

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Abstract:

The possible biological activities of a water soluble polysaccharide from Morchella esculenta (L.) Pers. named PMEP-1 were tested with peroxisome proliferator-activated receptor (PPAR) models related to blood lipid metabolism, and proliferation of tumor cells by high-throughput screening (HTS). PMEP-1 had slight activation effects on PPARδ models but no effects on PPAR α models. Animal experiments showed that TG in experiment groups (low dose 100 mg/kg·d, medium dose 200 mg/kg·d and high dose 400 mg/kg· d) was significantly (P< 0.05) lower than that in hyperlipidemic model group, the LDL-C content and the AI in low- and medium-dose groups were significantly (P< 0.05) lower than those in hyperlipidemic model group, while no significant differences in TC and HDL-C were seen among all the experiment groups and hyperlipidemic model group. So we concluded that PMEP-1 has hyperlipidemic acticity, and can prevent hyperlipidemia, coronary disease and atherosclerosis.

Key words: Morchella esculenta (L.) Pers, polysaccharide, hyperlipidemic activity, HTS

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