FOOD SCIENCE ›› 2009, Vol. 30 ›› Issue (19 ): 307-308.doi: 10.7506/spkx1002-6630-200919073

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Effects of Momordica charantia L. Saponins on Blood Lipids in Rats

YANG Zhi-gang,SHI Wan-zhen,SHEN Zong-gen,ZHANG Yan-ping,LI Meng   

  1. (Changshu Institute of Technology, Changshu 215500, China
  • Received:2009-06-15 Online:2009-10-01 Published:2010-12-29
  • Contact: YANG Zhi-gang, E-mail:15328844@qq.com

Abstract:

In order to understand effects of Momordica charantia L. saponins on blood lipids, the change of blood lipid profile in ovariectomized and hyperlipoidemia rats was determined after treated with Momordica charantia L. saponins at doses of 65, 130 and 260 mg/kg/day for 12weeks and 20 days, respectively. Results indicated that Momordica charantia L. saponins at doses of 130 and 260 mg/kg·d significantly decreased total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C) in serum of ovariectomized rats. Meanwhile, Momordica charantia L. saponins at dose of 130 and 260 mg/kg also obviously inhibited the increase of TC, LDL-C and triglyceride (TG) in a dose-dependent mode. Therefore, Momordica charantia L. saponins reveals a significant reduction effect on blood lipids in rats with hyperlipoidemia.

Key words: Momordica charantia L. saponins, lipid-lowering drugs, rat

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