FOOD SCIENCE ›› 2010, Vol. 31 ›› Issue (9): 229-233.doi: 10.7506/spkx1002-6630-201009051

• Nutrition & Hygiene • Previous Articles     Next Articles

Effect of Polysaccharides from Vitis viniferal L. on Immune Function in Mice

YU Dan1,ZHAO Jun2,LIU Tao1,SU De-qi1,MA Long1,*   

  1. 1. Department of Toxicology, College of Public Health, Xinjiang Medical University, Urumqi 830011, China;2. Xinjiang Key
    Laboratory for Research and Development of Uighur Drugs, Institute of Materia Medica of Xinjiang, Urumqi 830002, China
  • Received:2009-07-01 Online:2010-05-01 Published:2010-12-29
  • Contact: MA Long E-mail:ydwwl@163.com

Abstract:

Objectives: To study the effect of polysaccharides from Vitis viniferal L. (VTP) on immune function in mice. Methods: VTP was extracted using water and precipitated using 95% ethanol. The content of VTP was assayed with phenol-vitriolic colorimetry. Immunosuppressed mice were induced by cyclophosphamide and their indices of thymus and spleen, antibodysecreting cell function, serum hemolysin level and lymphocyte transformation capability were measured. Results: The content of polysaccharides in VTP crude extract was 20.68% with the RSD of 1.93%. Compared with the model group, VTP could increase spleen weight of mice, significantly promote lymphocyte transformation capability and antibody-secreting cell function, and improve serum hemolysin level. Conclusion: VTP could improve both humoral immune function and cellular immune function of immunosuppressed mice.

Key words: Vitis viniferal L., polysaccharides, immune function

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