Abstract:

Objective: To explore the anti-fatigue effect and mechanism of polysaccharides from Eleagnus angustifolius L. Methods: A total of 192 Kunming mice were randomly divided into 4 batches, each of which consisted of 4 groups: EAP groups at the dosages of low (100 mg/(kg bw·d)), middle (500 mg/(kg bw·d)) and high (1000 mg/(kg bw·d)) levels, and the control group. Each mouse was administered once a day for 30 days. After the end of the administration, all the mice were evaluated for their weight-loaded swimming duration and the contents of hepatic glycogen, blood urea nitrogen and blood lactic acid. Results: EAP at the high and middle dosages could prolong weight-loaded swimming duration, and decrease blood lactic acid level of mice. Hepatic glycogen content exhibited an increase in all groups administered EAP. In addition, a decline of blood urea nitrogen was observed in mice administered EAP at the high and low dosages. Conclusion: EAP could alleviate physical fatigue of mice.

Key words: polysaccharides from Eleagnus angustifolius L., anti-fatigue effect, mechanism, health-care food