Abstract:

The impregnation of vitamin D3 into chitosan particles using supercritical CO2 fluid was investigated with respect to the effects of pressure, temperature and length of impregnation time evaluated by UV-vis spectroscopy. The results showed that with increasing pressure, VD3 impregnation amount initially increased and then decreased; as temperature increased, an identical change pattern in VD3 impregnation amount was observed. VD3 impregnation amount reached its maximum value under the conditions of 20 MPa and 35 ℃. Increasing length of impregnation time from 1 to 3 h resulted in a higher VD3 impregnation amount when pressure and temperature kept unchangeable.

Key words: supercritical CO2 impregnation, vitamin D3, chitosan